Innate Immune Cells in Liver Inflammation
Innate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host. Human liver is characterised by a dual blood supply, with 80% of blood entering through the portal vein carrying nutrients and bacterial endotoxin from the gastrointest...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/949157 |
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| _version_ | 1832563025442242560 |
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| author | Evaggelia Liaskou Daisy V. Wilson Ye H. Oo |
| author_facet | Evaggelia Liaskou Daisy V. Wilson Ye H. Oo |
| author_sort | Evaggelia Liaskou |
| collection | DOAJ |
| description | Innate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host. Human liver is characterised by a dual blood supply, with 80% of blood entering through the portal vein carrying nutrients and bacterial endotoxin from the gastrointestinal tract. The liver is thus constantly exposed to antigenic loads. Therefore, pathogenic microorganism must be efficiently eliminated whilst harmless antigens derived from the gastrointestinal tract need to be tolerized in the liver. In order to achieve this, the liver innate immune system is equipped with multiple cellular components; monocytes, macrophages, granulocytes, natural killer cells, and dendritic cells which coordinate to exert tolerogenic environment at the same time detect, respond, and eliminate invading pathogens, infected or transformed self to mount immunity. This paper will discuss the innate immune cells that take part in human liver inflammation, and their roles in both resolution of inflammation and tissue repair. |
| format | Article |
| id | doaj-art-777f4b4fc2bf430898f8bebd9efadf97 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-777f4b4fc2bf430898f8bebd9efadf972025-02-03T01:21:16ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/949157949157Innate Immune Cells in Liver InflammationEvaggelia Liaskou0Daisy V. Wilson1Ye H. Oo2Centre for Liver Research & NIHR BRU in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UKRespiratory Medicine Department, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham B15 2TH, UKCentre for Liver Research & NIHR BRU in Liver Disease, Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UKInnate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host. Human liver is characterised by a dual blood supply, with 80% of blood entering through the portal vein carrying nutrients and bacterial endotoxin from the gastrointestinal tract. The liver is thus constantly exposed to antigenic loads. Therefore, pathogenic microorganism must be efficiently eliminated whilst harmless antigens derived from the gastrointestinal tract need to be tolerized in the liver. In order to achieve this, the liver innate immune system is equipped with multiple cellular components; monocytes, macrophages, granulocytes, natural killer cells, and dendritic cells which coordinate to exert tolerogenic environment at the same time detect, respond, and eliminate invading pathogens, infected or transformed self to mount immunity. This paper will discuss the innate immune cells that take part in human liver inflammation, and their roles in both resolution of inflammation and tissue repair.http://dx.doi.org/10.1155/2012/949157 |
| spellingShingle | Evaggelia Liaskou Daisy V. Wilson Ye H. Oo Innate Immune Cells in Liver Inflammation Mediators of Inflammation |
| title | Innate Immune Cells in Liver Inflammation |
| title_full | Innate Immune Cells in Liver Inflammation |
| title_fullStr | Innate Immune Cells in Liver Inflammation |
| title_full_unstemmed | Innate Immune Cells in Liver Inflammation |
| title_short | Innate Immune Cells in Liver Inflammation |
| title_sort | innate immune cells in liver inflammation |
| url | http://dx.doi.org/10.1155/2012/949157 |
| work_keys_str_mv | AT evaggelialiaskou innateimmunecellsinliverinflammation AT daisyvwilson innateimmunecellsinliverinflammation AT yehoo innateimmunecellsinliverinflammation |