A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes
We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected for all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe DKA (pH < 7.1), DKA in preschool children, DKA t...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5719470 |
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| author | Stefano Zucchini Andrea E. Scaramuzza Riccardo Bonfanti Pietro Buono Francesca Cardella Vittoria Cauvin Valentino Cherubini Giovanni Chiari Giuseppe d’Annunzio Anna Paola Frongia Dario Iafusco Giulio Maltoni Ippolita Patrizia Patera Sonia Toni Stefano Tumini Ivana Rabbone Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) |
| author_facet | Stefano Zucchini Andrea E. Scaramuzza Riccardo Bonfanti Pietro Buono Francesca Cardella Vittoria Cauvin Valentino Cherubini Giovanni Chiari Giuseppe d’Annunzio Anna Paola Frongia Dario Iafusco Giulio Maltoni Ippolita Patrizia Patera Sonia Toni Stefano Tumini Ivana Rabbone Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) |
| author_sort | Stefano Zucchini |
| collection | DOAJ |
| description | We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected for all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe DKA (pH < 7.1), DKA in preschool children, DKA treatment according to ISPAD protocol, type of rehydrating solution used, bicarbonates use, and amount of insulin infused. Records (n=2453) of children with newly diagnosed diabetes were collected from 68/77 centers (87%), 39 of which are tertiary referral centers, the majority of whom (n=1536, 89.4%) were diagnosed in the tertiary referral centers. DKA was observed in 38.5% and severe DKA in 10.3%. Considering preschool children, DKA was observed in 72%, and severe DKA in 16.7%. Cerebral edema following DKA treatment was observed in 5 (0.5%). DKA treatment according to ISPAD guidelines was adopted in 68% of the centers. In the first 2 hours, rehydration was started with normal saline in all centers, but with different amount. Bicarbonate was quite never been used. Insulin was infused starting from third hour at the rate of 0.05–0.1 U/kg/h in 72% of centers. Despite prevention campaign, DKA is still observed in Italian children at onset, with significant variability in DKA treatment, underlying the need to share guidelines among centers. |
| format | Article |
| id | doaj-art-777cef8160c7450a841d5d07cb797fd4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-777cef8160c7450a841d5d07cb797fd42025-02-03T06:05:19ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/57194705719470A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 DiabetesStefano Zucchini0Andrea E. Scaramuzza1Riccardo Bonfanti2Pietro Buono3Francesca Cardella4Vittoria Cauvin5Valentino Cherubini6Giovanni Chiari7Giuseppe d’Annunzio8Anna Paola Frongia9Dario Iafusco10Giulio Maltoni11Ippolita Patrizia Patera12Sonia Toni13Stefano Tumini14Ivana Rabbone15Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED)16Department of Pediatrics, S. Orsola-Malpighi Hospital, Via Albertoni 15, 40138 Bologna, ItalyDepartment of Pediatrics, Azienda Ospedaliera, “Ospedale Luigi Sacco”, University of Milan, Via G.B. Grassi 74, 20157 Milan, ItalyDepartment of Pediatrics, Endocrine Unit, Scientific Institute Hospital San Raffaele, Vita-Salute University, Via Olgettina 60, 20132 Milan, ItalyUOSD Pediatric Diabetology, ASL NA2 Nord, Via Corrado Alvaro 8, Monteruscello, 80072 Pozzuoli, ItalyDepartment of Pediatrics, U.O.S. Pediatric Diabetology, ARNAS Civico Di Cristina, Via Benedettini 1, 90134 Palermo, ItalyPediatric Unit, S. Chiara Hospital, Largo Medaglie d’Oro 9, 38122 Trento, ItalyRegional Center for Diabetes in Children and Adolescents, Department of Woman and Child Health, AOU Salesi Hospital, Via Corridoni 11, 60123 Ancona, ItalyPostgraduate School of Pediatrics, University of Parma, Viale Gramsci 14, 43100 Parma, ItalyClinica Pediatrica, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147 Genova, ItalyUnit of Pediatric Diabetes, Brotzu Hospital, Piazzale Ricchi 1, 09134 Cagliari, ItalyDepartment of Pediatrics, Second University of Naples, Via S. Andrea delle Dame 4, 80138 Naples, ItalyDepartment of Pediatrics, S. Orsola-Malpighi Hospital, Via Albertoni 15, 40138 Bologna, ItalyEndocrinology and Diabetes Unit, University Department of Pediatric Medicine, Bambino Gesù Children’s Hospital, Piazza Sant’Onofrio 4, 00165 Rome, ItalyJuvenile Diabetes Center, Anna Meyer Children’s Hospital, Via Pieraccini 24, 50132 Florence, ItalyCenter of Pediatric Diabetology, University of Chieti, 66100 Chieti, ItalyDepartment of Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, ItalyDepartment of Pediatrics, University of Turin, Piazza Polonia 94, 10126 Turin, ItalyWe conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected for all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe DKA (pH < 7.1), DKA in preschool children, DKA treatment according to ISPAD protocol, type of rehydrating solution used, bicarbonates use, and amount of insulin infused. Records (n=2453) of children with newly diagnosed diabetes were collected from 68/77 centers (87%), 39 of which are tertiary referral centers, the majority of whom (n=1536, 89.4%) were diagnosed in the tertiary referral centers. DKA was observed in 38.5% and severe DKA in 10.3%. Considering preschool children, DKA was observed in 72%, and severe DKA in 16.7%. Cerebral edema following DKA treatment was observed in 5 (0.5%). DKA treatment according to ISPAD guidelines was adopted in 68% of the centers. In the first 2 hours, rehydration was started with normal saline in all centers, but with different amount. Bicarbonate was quite never been used. Insulin was infused starting from third hour at the rate of 0.05–0.1 U/kg/h in 72% of centers. Despite prevention campaign, DKA is still observed in Italian children at onset, with significant variability in DKA treatment, underlying the need to share guidelines among centers.http://dx.doi.org/10.1155/2016/5719470 |
| spellingShingle | Stefano Zucchini Andrea E. Scaramuzza Riccardo Bonfanti Pietro Buono Francesca Cardella Vittoria Cauvin Valentino Cherubini Giovanni Chiari Giuseppe d’Annunzio Anna Paola Frongia Dario Iafusco Giulio Maltoni Ippolita Patrizia Patera Sonia Toni Stefano Tumini Ivana Rabbone Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology (ISPED) A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes Journal of Diabetes Research |
| title | A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes |
| title_full | A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes |
| title_fullStr | A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes |
| title_full_unstemmed | A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes |
| title_short | A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes |
| title_sort | multicenter retrospective survey regarding diabetic ketoacidosis management in italian children with type 1 diabetes |
| url | http://dx.doi.org/10.1155/2016/5719470 |
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