An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review
Therapy-related myeloid neoplasm (t-MN) is a late and lethal complication induced by chemotherapy and/or radiation therapy. Hematological malignancy is one of the most common primary diseases in patients with t-MN. However, the occurrence of t-MN in adult T-cell leukemia/lymphoma (ATL) patients is r...
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| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/4532434 |
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| author | Reina Takeda Kazuaki Yokoyama Seiichiro Kobayashi Toyotaka Kawamata Sousuke Nakamura Tomofusa Fukuyama Mika Ito Nozomi Yusa Eigo Shimizu Nobuhiro Ohno Rui Yamaguchi Seiya Imoto Satoru Miyano Kaoru Uchimaru Arinobu Tojo |
| author_facet | Reina Takeda Kazuaki Yokoyama Seiichiro Kobayashi Toyotaka Kawamata Sousuke Nakamura Tomofusa Fukuyama Mika Ito Nozomi Yusa Eigo Shimizu Nobuhiro Ohno Rui Yamaguchi Seiya Imoto Satoru Miyano Kaoru Uchimaru Arinobu Tojo |
| author_sort | Reina Takeda |
| collection | DOAJ |
| description | Therapy-related myeloid neoplasm (t-MN) is a late and lethal complication induced by chemotherapy and/or radiation therapy. Hematological malignancy is one of the most common primary diseases in patients with t-MN. However, the occurrence of t-MN in adult T-cell leukemia/lymphoma (ATL) patients is rarely reported, possibly due to the dismal prognosis of ATL per se. Here, we report a 62-year-old female who developed t-MN only three months after the completion of conventional chemotherapy and anti-CCR4 antibody for ATL acute type. The patient presented with persistent fever and monocytosis without any evidence of infectious diseases. Bone marrow examinations revealed chronic myelomonocytic leukemia-like disease with a chromosomal translocation of t(11;22)(q23;q13) as a solo cytogenetic abnormality, resulting in the diagnosis of t-MN. Next-generation sequencing analysis identified a rare chimeric transcript, MLL-EP300, without any additional somatic mutations. Although the patient underwent allogenic hematopoietic stem cell transplantation, she died of viral encephalomyelitis at 7 months after diagnosis of t-MN. Since recent therapeutic advances have extended the survival of patients with ATL, further evaluation of the long-term risks of developing t-MN in these patients is warranted. |
| format | Article |
| id | doaj-art-7773078cd9084e338dd069aafcb2fb5e |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-7773078cd9084e338dd069aafcb2fb5e2025-02-03T01:12:27ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/45324344532434An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature ReviewReina Takeda0Kazuaki Yokoyama1Seiichiro Kobayashi2Toyotaka Kawamata3Sousuke Nakamura4Tomofusa Fukuyama5Mika Ito6Nozomi Yusa7Eigo Shimizu8Nobuhiro Ohno9Rui Yamaguchi10Seiya Imoto11Satoru Miyano12Kaoru Uchimaru13Arinobu Tojo14Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDivision of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDivision of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDivision of Molecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Applied Genomics, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDivision of Health Medical Data Science, Health Intelligence Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanLaboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, JapanTherapy-related myeloid neoplasm (t-MN) is a late and lethal complication induced by chemotherapy and/or radiation therapy. Hematological malignancy is one of the most common primary diseases in patients with t-MN. However, the occurrence of t-MN in adult T-cell leukemia/lymphoma (ATL) patients is rarely reported, possibly due to the dismal prognosis of ATL per se. Here, we report a 62-year-old female who developed t-MN only three months after the completion of conventional chemotherapy and anti-CCR4 antibody for ATL acute type. The patient presented with persistent fever and monocytosis without any evidence of infectious diseases. Bone marrow examinations revealed chronic myelomonocytic leukemia-like disease with a chromosomal translocation of t(11;22)(q23;q13) as a solo cytogenetic abnormality, resulting in the diagnosis of t-MN. Next-generation sequencing analysis identified a rare chimeric transcript, MLL-EP300, without any additional somatic mutations. Although the patient underwent allogenic hematopoietic stem cell transplantation, she died of viral encephalomyelitis at 7 months after diagnosis of t-MN. Since recent therapeutic advances have extended the survival of patients with ATL, further evaluation of the long-term risks of developing t-MN in these patients is warranted.http://dx.doi.org/10.1155/2019/4532434 |
| spellingShingle | Reina Takeda Kazuaki Yokoyama Seiichiro Kobayashi Toyotaka Kawamata Sousuke Nakamura Tomofusa Fukuyama Mika Ito Nozomi Yusa Eigo Shimizu Nobuhiro Ohno Rui Yamaguchi Seiya Imoto Satoru Miyano Kaoru Uchimaru Arinobu Tojo An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review Case Reports in Hematology |
| title | An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review |
| title_full | An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review |
| title_fullStr | An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review |
| title_full_unstemmed | An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review |
| title_short | An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review |
| title_sort | unusually short latent period of therapy related myeloid neoplasm harboring a rare mll ep300 rearrangement case report and literature review |
| url | http://dx.doi.org/10.1155/2019/4532434 |
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