Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior
Abstract Background Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural basis underlying this association remain unclear. The potential reasons for the inconsistent findings may be...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06485-0 |
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| author | Yuan Li Ting Zhang Xin Hou Xiaoyi Chen Yu Mao |
| author_facet | Yuan Li Ting Zhang Xin Hou Xiaoyi Chen Yu Mao |
| author_sort | Yuan Li |
| collection | DOAJ |
| description | Abstract Background Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural basis underlying this association remain unclear. The potential reasons for the inconsistent findings may be attributed to the involvement of both common and specific neural pathways that mediate the influence of childhood maltreatment on the emergence of psychopathological conditions. Methods This study aimed to delineate both the common and distinct neural pathways linking childhood maltreatment to depression and aggression. First, we employed Network-Based Statistics (NBS) on resting-state functional magnetic resonance imaging (fMRI) data to identify functional connectivity (FC) patterns associated with depression and aggression. Mediation analyses were then conducted to assess the role of these FC patterns in the relationship between childhood maltreatment and each outcome. Results The results demonstrated that FC within the default mode network (DMN) and between the cingulo-opercular network (CON) and dorsal attention network (DAN) mediated the association between childhood maltreatment and aggression, whereas FC within the reward system and between the CON and the reward system mediated the link between childhood maltreatment and depression. Conclusions We speculate that the control system may serve as a transdiagnostic neural basis accounting for the sequela of childhood maltreatment, and the attention network and the reward network may act as specific neural basis linking childhood maltreatment to depression and aggression, respectively. |
| format | Article |
| id | doaj-art-776ec11f1da247faae0dc30ec342c498 |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-776ec11f1da247faae0dc30ec342c4982025-01-19T12:34:23ZengBMCBMC Psychiatry1471-244X2025-01-0125111210.1186/s12888-025-06485-0Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behaviorYuan Li0Ting Zhang1Xin Hou2Xiaoyi Chen3Yu Mao4School of Education, Chongqing Normal UniversityDepartment of Medical Psychology, Daping Hospital, Army Medical UniversitySchool of Education, Chongqing Normal UniversitySchool of Education, Chongqing Normal UniversityCollege of Artificial Intelligence, Southwest UniversityAbstract Background Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural basis underlying this association remain unclear. The potential reasons for the inconsistent findings may be attributed to the involvement of both common and specific neural pathways that mediate the influence of childhood maltreatment on the emergence of psychopathological conditions. Methods This study aimed to delineate both the common and distinct neural pathways linking childhood maltreatment to depression and aggression. First, we employed Network-Based Statistics (NBS) on resting-state functional magnetic resonance imaging (fMRI) data to identify functional connectivity (FC) patterns associated with depression and aggression. Mediation analyses were then conducted to assess the role of these FC patterns in the relationship between childhood maltreatment and each outcome. Results The results demonstrated that FC within the default mode network (DMN) and between the cingulo-opercular network (CON) and dorsal attention network (DAN) mediated the association between childhood maltreatment and aggression, whereas FC within the reward system and between the CON and the reward system mediated the link between childhood maltreatment and depression. Conclusions We speculate that the control system may serve as a transdiagnostic neural basis accounting for the sequela of childhood maltreatment, and the attention network and the reward network may act as specific neural basis linking childhood maltreatment to depression and aggression, respectively.https://doi.org/10.1186/s12888-025-06485-0Childhood maltreatmentDepressionAggressionControl systemAttention networkReward system |
| spellingShingle | Yuan Li Ting Zhang Xin Hou Xiaoyi Chen Yu Mao Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior BMC Psychiatry Childhood maltreatment Depression Aggression Control system Attention network Reward system |
| title | Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| title_full | Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| title_fullStr | Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| title_full_unstemmed | Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| title_short | Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| title_sort | common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior |
| topic | Childhood maltreatment Depression Aggression Control system Attention network Reward system |
| url | https://doi.org/10.1186/s12888-025-06485-0 |
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