Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), which is highly expressed in the central nervous system, is known to be involved in the regulation of mitochondrial biosynthesis, metabolic regulation, neuroinflammation, autophagy, and oxidative stress. This knowledge indicates a...

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Bibliographic Details
Main Authors: Mi-bo Tang, Yi-xuan Liu, Zheng-wei Hu, Hai-yang Luo, Shuo Zhang, Chang-he Shi, Yu-ming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
PGC-1α
mitochondria
neuroinflammation
oxidative stress
neurological diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1454735/full
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