Mechanical cues rewire lipid metabolism and support chemoresistance in epithelial ovarian cancer cell lines OVCAR3 and SKOV3

Mechanical cues rewire lipid metabolism and support chemoresistance in epithelial ovarian cancer cell lines OVCAR3 and SKOV3

Abstract Epithelial ovarian cancer (EOC) is one of the deadliest cancers in women, and acquired chemoresistance is a major contributor of aggressive phenotypes. Overcoming treatment failure and disease recurrence is therefore an ambitious goal. Ovarian cancer develops in a biophysically challenging...

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Bibliographic Details
Main Authors: Martina Karasová, Maximilian Jobst, Denise Framke, Janice Bergen, Samuel Meier-Menches, Bernhard Keppler, Gunda Koellensperger, Jürgen Zanghellini, Christopher Gerner, Giorgia Del Favero
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Ovarian cancer
Mechanotransduction
Mechanosensitive transcription factors
SREBP2
YAP1
Lipid metabolism
Online Access:https://doi.org/10.1186/s12964-025-02144-9
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