Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies
Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinica...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/302894 |
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| _version_ | 1832549105831772160 |
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| author | Kristina A. Trujillo Anna C. Jones Jeffrey K. Griffith Marco Bisoffi |
| author_facet | Kristina A. Trujillo Anna C. Jones Jeffrey K. Griffith Marco Bisoffi |
| author_sort | Kristina A. Trujillo |
| collection | DOAJ |
| description | Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions. |
| format | Article |
| id | doaj-art-7748df44deb94a91bcd96cda347a5c2a |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-7748df44deb94a91bcd96cda347a5c2a2025-02-03T06:12:09ZengWileyProstate Cancer2090-31112090-312X2012-01-01201210.1155/2012/302894302894Markers of Field Cancerization: Proposed Clinical Applications in Prostate BiopsiesKristina A. Trujillo0Anna C. Jones1Jeffrey K. Griffith2Marco Bisoffi3Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USADepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USADepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USADepartment of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USAField cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues adjacent to cancerous lesions. This paper tabulates markers of prostate field cancerization known to date and discusses their potential clinical value in the analysis of prostate biopsies, including diagnosis, monitoring progression during active surveillance, and assessing efficacy of presurgical neoadjuvant and focal therapeutic interventions.http://dx.doi.org/10.1155/2012/302894 |
| spellingShingle | Kristina A. Trujillo Anna C. Jones Jeffrey K. Griffith Marco Bisoffi Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies Prostate Cancer |
| title | Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies |
| title_full | Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies |
| title_fullStr | Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies |
| title_full_unstemmed | Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies |
| title_short | Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies |
| title_sort | markers of field cancerization proposed clinical applications in prostate biopsies |
| url | http://dx.doi.org/10.1155/2012/302894 |
| work_keys_str_mv | AT kristinaatrujillo markersoffieldcancerizationproposedclinicalapplicationsinprostatebiopsies AT annacjones markersoffieldcancerizationproposedclinicalapplicationsinprostatebiopsies AT jeffreykgriffith markersoffieldcancerizationproposedclinicalapplicationsinprostatebiopsies AT marcobisoffi markersoffieldcancerizationproposedclinicalapplicationsinprostatebiopsies |