Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion
Treatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental he...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2021/5525398 |
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| _version_ | 1832560603470757888 |
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| author | Zoe Harrison Owen Haeney William Brereton |
| author_facet | Zoe Harrison Owen Haeney William Brereton |
| author_sort | Zoe Harrison |
| collection | DOAJ |
| description | Treatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental health services, residual symptomatology often presents a barrier to discharge and can have lasting effects on prospects for rehabilitation as well as risk to self and others. This paper presents a review of the relevant literature and three cases of a novel approach, utilising clozapine in doses usually considered subtherapeutic, in combination with the primary antipsychotic treatment. In all three patients, it improved clinical efficacy as well as tolerability, resulting in improvement that allowed discharge from the forensic hospital. |
| format | Article |
| id | doaj-art-77419fb48e654c139e041a1ba5de97dd |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-77419fb48e654c139e041a1ba5de97dd2025-02-03T01:27:06ZengWileyCase Reports in Psychiatry2090-682X2090-68382021-01-01202110.1155/2021/55253985525398Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and DiscussionZoe Harrison0Owen Haeney1William Brereton2University of Adelaide, Faculty of Health and Medical Sciences, 4 North Terrace, Adelaide South Australia 5000, AustraliaUniversity of Adelaide, Faculty of Health and Medical Sciences, 4 North Terrace, Adelaide South Australia 5000, AustraliaUniversity of Adelaide, Faculty of Health and Medical Sciences, 4 North Terrace, Adelaide South Australia 5000, AustraliaTreatment resistance in schizophrenia is often encountered in clinical practice, with clozapine usually recommended as the appropriate therapy. However, where clozapine proves ineffective or cannot be tolerated due to side effects, treatment options are limited. In patients within forensic mental health services, residual symptomatology often presents a barrier to discharge and can have lasting effects on prospects for rehabilitation as well as risk to self and others. This paper presents a review of the relevant literature and three cases of a novel approach, utilising clozapine in doses usually considered subtherapeutic, in combination with the primary antipsychotic treatment. In all three patients, it improved clinical efficacy as well as tolerability, resulting in improvement that allowed discharge from the forensic hospital.http://dx.doi.org/10.1155/2021/5525398 |
| spellingShingle | Zoe Harrison Owen Haeney William Brereton Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion Case Reports in Psychiatry |
| title | Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion |
| title_full | Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion |
| title_fullStr | Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion |
| title_full_unstemmed | Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion |
| title_short | Augmentation of Antipsychotic Medications with Low-Dose Clozapine in Treatment-Resistant Schizophrenia—Case Reports and Discussion |
| title_sort | augmentation of antipsychotic medications with low dose clozapine in treatment resistant schizophrenia case reports and discussion |
| url | http://dx.doi.org/10.1155/2021/5525398 |
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