Is the use of anthracyclines implicated in myocardial injury? Investigating the cardio modulatory effects of naringenin and apocynin in doxorubicin-induced cardiotoxicity in rats

Is the use of anthracyclines implicated in myocardial injury? Investigating the cardio modulatory effects of naringenin and apocynin in doxorubicin-induced cardiotoxicity in rats

Naringenin, a major flavonoid in oranges, grapefruit, tomato skin and apocynin a polyphenolic compound isolated from plants, such as Apocynum cannabinum are known to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. Doxorubicin (DOX) is an antibiotic, effective in the treatment of...

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Bibliographic Details
Main Authors: Justin Atiang Beshel, Samuel Usoh Ukweni, Idara Asuquo Okon, Daniel Udofia Owu
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Toxicology Reports
Subjects:
Cardiac toxicity
Doxorubicin
Naringenin
Apocynin
Hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750025002355
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