The efficacy of hydrothermally obtained carbonated hydroxyapatite in healing alveolar bone defects in rats with or without corticosteroid treatment
Background/Aim. Autogenous bone grafting has been the gold standard in clinical cases when bone grafts are required for bone defects in dentistry. The study was undertaken to evaluate multilevel designed carbonated hydroxyapatite (CHA) obtained by hydrothermal method, as a bone substitute i...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2014-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2014/0042-84501405462M.pdf |
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| Summary: | Background/Aim. Autogenous bone grafting has been the gold standard in
clinical cases when bone grafts are required for bone defects in dentistry.
The study was undertaken to evaluate multilevel designed carbonated
hydroxyapatite (CHA) obtained by hydrothermal method, as a bone substitute in
healing bone defects with or without corticosteroid treatment in rats as
assessed by histopathologic methods. Methods. Bone defects were created in
the alveolar bone by teeth extraction in 12 rats. The animals were initially
divided into two groups. The experimental group was pretreated with
corticosteroids: methylprednisolone and dexamethasone, intramuscularly, while
the control group was without therapy. Posterior teeth extraction had been
performed after the corticosteroid therapy. The extraction defects were
fulfilled with hydroxyapatite with bimodal particle sizes in the range of
50-250 μm and the sample from postextocactional defect of the alveolar bone
was analyzed pathohystologically. Results. The histopatological
investigations confirmed the biologic properties of the applied material. The
evident growth of new bone in the alveolar ridge was clearly noticed in both
groups of rats. Carbonated HA obtained by hydrothermal method promoted bone
formation in the preformed defects, confirming its efficacy for usage in bone
defects. Complete resorption of the material’s particles took place after 25
weeks. Conclusion. Hydroxyapatite completely meets the clinical requirements
for a bone substitute material. Due to its microstructure, complete
resorption took place during the observation period of the study.
Corticosteroid treatment did not significantly affect new bone formation in
the region of postextractional defects. [Projekat Ministarstva nauke
Republike Srbije, br. 172026] |
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| ISSN: | 0042-8450 |