Hierarchical progressive learning for zero-shot peptide-HLA binding prediction and automated antigenic peptide design

Summary: Predicting the binding of peptides to human leukocyte antigen (HLA) alleles is critical for identifying epitopes initiating immune responses in vaccine development and immunotherapies. Despite the progress in predicting binding peptides of 1% HLA class-I alleles with in silico prediction to...

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Bibliographic Details
Main Authors: Xinyuan Zhu, Jiadong Lu, Xinting Hu, Tengchuan Jin, Shan Lu, Fuli Feng
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005340
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