Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma

Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma

Abstract Background About 50% of cutaneous melanoma (CM) harbors the activating BRAFV600 mutation which exerts most of the oncogenic effects through the MAPK signaling pathway. In the last years, a number of MAPK modulators have been identified, including Spry1. In this context, we have recently dem...

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Main Authors: Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Annamaria Salvati, Giovanni Nassa, Jessica Lamberti, Domenico Memoli, Patrizia Sabatelli, Marina Comelli, Arianna Bellazzo, Albina Fejza, Lucrezia Camicia, Lorena Baboci, Michele Dal Bo, Alessia Covre, Tuula A. Nyman, Alessandro Weisz, Agostino Steffan, Michele Maio, Luca Sigalotti, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Spry1
HIF1α
Cutaneous melanoma
BRAF
Mitochondria
Online Access:https://doi.org/10.1186/s13046-025-03289-8
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