Secondary infections in COVID-19: Antemortem and postmortem culture study
Background: Secondary bacterial infections during COVID-19 hospitalization have been reported in about 6–15% of patients. Aims: To study the secondary bacterial infections that affected the COVID-19 patients during their hospitalisation and to unearth the bacteriological profile of samples obtained...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_141_22 |
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| author | Vandana V. Kiro Meenakshi Sharma Sharad Srivastava Parin Lalwani Richa Aggarwal Kapil D. Soni Rajesh Malhotra Sanjeev Lalwani Purva Mathur Anjan Trikha |
| author_facet | Vandana V. Kiro Meenakshi Sharma Sharad Srivastava Parin Lalwani Richa Aggarwal Kapil D. Soni Rajesh Malhotra Sanjeev Lalwani Purva Mathur Anjan Trikha |
| author_sort | Vandana V. Kiro |
| collection | DOAJ |
| description | Background:
Secondary bacterial infections during COVID-19 hospitalization have been reported in about 6–15% of patients.
Aims:
To study the secondary bacterial infections that affected the COVID-19 patients during their hospitalisation and to unearth the bacteriological profile of samples obtained after their demise.
Settings and Design:
This prospective study was carried out at a COVID-19 dedicated, apex tertiary care centre in North India from July 2020 to April 2021.
Methods and Materials:
Samples of 268 patients were considered for the study. Nasopharyngeal swab specimen, blood, and tissue (lung) were collected from the deceased body as early as possible and processed.
Statistical Analysis:
Statistical analyses were performed using STATA version 11.1 (Stata Corp., College Station, TX, USA).
Results:
A total of 170 samples were received from patients before their death, which included blood, urine, respiratory samples, pus, and cerebrospinal fluid. Forty-four pathogens were isolated, which consisted of Acinetobacter baumannii (43.1%), Klebsiella pneumoniae (36.3%), Escherichia coli (11.3%), and Pseudomonas aeruginosa (4.5%), Enterococcus faecium (4.5%). Two hundred fifty-eight samples were collected from the deceased bodies wherein the nasopharyngeal sample was highest, followed by tissue and blood. A total of 43 pathogens were isolated among them which included A. baumannii (44.1%), followed by K. pneumoniae (25.5%), E. coli (20.9%), P. aeruginosa (6.97%) and Enterobacter cloacae (2.3%). All these isolates were highly resistant to antimicrobials.
Conclusions:
In our study, bacterial profiles in antemortem and postmortem samples were found to be similar, suggesting that resistant pathogens may be the cause of mortality in COVID-19 infected hospitalised patients. |
| format | Article |
| id | doaj-art-76ee492eddab41e093b20f21ba5c400f |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-76ee492eddab41e093b20f21ba5c400f2025-01-22T15:08:50ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-04-01671515510.4103/ijpm.ijpm_141_22Secondary infections in COVID-19: Antemortem and postmortem culture studyVandana V. KiroMeenakshi SharmaSharad SrivastavaParin LalwaniRicha AggarwalKapil D. SoniRajesh MalhotraSanjeev LalwaniPurva MathurAnjan TrikhaBackground: Secondary bacterial infections during COVID-19 hospitalization have been reported in about 6–15% of patients. Aims: To study the secondary bacterial infections that affected the COVID-19 patients during their hospitalisation and to unearth the bacteriological profile of samples obtained after their demise. Settings and Design: This prospective study was carried out at a COVID-19 dedicated, apex tertiary care centre in North India from July 2020 to April 2021. Methods and Materials: Samples of 268 patients were considered for the study. Nasopharyngeal swab specimen, blood, and tissue (lung) were collected from the deceased body as early as possible and processed. Statistical Analysis: Statistical analyses were performed using STATA version 11.1 (Stata Corp., College Station, TX, USA). Results: A total of 170 samples were received from patients before their death, which included blood, urine, respiratory samples, pus, and cerebrospinal fluid. Forty-four pathogens were isolated, which consisted of Acinetobacter baumannii (43.1%), Klebsiella pneumoniae (36.3%), Escherichia coli (11.3%), and Pseudomonas aeruginosa (4.5%), Enterococcus faecium (4.5%). Two hundred fifty-eight samples were collected from the deceased bodies wherein the nasopharyngeal sample was highest, followed by tissue and blood. A total of 43 pathogens were isolated among them which included A. baumannii (44.1%), followed by K. pneumoniae (25.5%), E. coli (20.9%), P. aeruginosa (6.97%) and Enterobacter cloacae (2.3%). All these isolates were highly resistant to antimicrobials. Conclusions: In our study, bacterial profiles in antemortem and postmortem samples were found to be similar, suggesting that resistant pathogens may be the cause of mortality in COVID-19 infected hospitalised patients.https://journals.lww.com/10.4103/ijpm.ijpm_141_22antemortemcovid-19multidrug-resistantpostmortemsecondary infections |
| spellingShingle | Vandana V. Kiro Meenakshi Sharma Sharad Srivastava Parin Lalwani Richa Aggarwal Kapil D. Soni Rajesh Malhotra Sanjeev Lalwani Purva Mathur Anjan Trikha Secondary infections in COVID-19: Antemortem and postmortem culture study Indian Journal of Pathology and Microbiology antemortem covid-19 multidrug-resistant postmortem secondary infections |
| title | Secondary infections in COVID-19: Antemortem and postmortem culture study |
| title_full | Secondary infections in COVID-19: Antemortem and postmortem culture study |
| title_fullStr | Secondary infections in COVID-19: Antemortem and postmortem culture study |
| title_full_unstemmed | Secondary infections in COVID-19: Antemortem and postmortem culture study |
| title_short | Secondary infections in COVID-19: Antemortem and postmortem culture study |
| title_sort | secondary infections in covid 19 antemortem and postmortem culture study |
| topic | antemortem covid-19 multidrug-resistant postmortem secondary infections |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_141_22 |
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