Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population
Purpose. To describe the clinical manifestations and treatment outcomes of syphilitic uveitis in a Chinese population. Methods. This is a retrospective case series of 15 consecutive patients with syphilitic uveitis treated at a uveitis referral center between 2012 and 2015. Results. Fifteen patients...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/2797028 |
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| _version_ | 1832566826453696512 |
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| author | Rui Zhang Jiang Qian Jie Guo Yifei Yuan Kang Xue Han Yue Ling Chen |
| author_facet | Rui Zhang Jiang Qian Jie Guo Yifei Yuan Kang Xue Han Yue Ling Chen |
| author_sort | Rui Zhang |
| collection | DOAJ |
| description | Purpose. To describe the clinical manifestations and treatment outcomes of syphilitic uveitis in a Chinese population. Methods. This is a retrospective case series of 15 consecutive patients with syphilitic uveitis treated at a uveitis referral center between 2012 and 2015. Results. Fifteen patients were diagnosed with syphilitic uveitis based on positive serological tests. Nine patients were male. Coinfection with human immunodeficiency virus was detected in two patients. Twenty eyes presented with panuveitis and all patients had posterior involvement. The most frequent manifestations were retinal vasculitis and papillitis, while syphilitic posterior placoid chorioretinitis was only found in three eyes. All patients received systemic penicillin therapy according to CDC guidelines. Nine patients were misdiagnosed before presenting to our center and the delay in treatment with penicillin was associated with poor final visual outcomes (P<0.05). Conclusions. In our series, both male and female were almost equally affected and coinfection of syphilis with human immunodeficiency virus was uncommon. All patients in this study had posterior involvement and the most common manifestations were retinal vasculitis and papillitis. Syphilis should be considered as an important differential diagnosis especially for posterior uveitis and panuveitis. Early diagnosis and appropriate treatment are important for visual prognosis. |
| format | Article |
| id | doaj-art-76ed1e05ee064d5a93d9e3a9f68b2d01 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-76ed1e05ee064d5a93d9e3a9f68b2d012025-02-03T01:03:09ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/27970282797028Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese PopulationRui Zhang0Jiang Qian1Jie Guo2Yifei Yuan3Kang Xue4Han Yue5Ling Chen6Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaPurpose. To describe the clinical manifestations and treatment outcomes of syphilitic uveitis in a Chinese population. Methods. This is a retrospective case series of 15 consecutive patients with syphilitic uveitis treated at a uveitis referral center between 2012 and 2015. Results. Fifteen patients were diagnosed with syphilitic uveitis based on positive serological tests. Nine patients were male. Coinfection with human immunodeficiency virus was detected in two patients. Twenty eyes presented with panuveitis and all patients had posterior involvement. The most frequent manifestations were retinal vasculitis and papillitis, while syphilitic posterior placoid chorioretinitis was only found in three eyes. All patients received systemic penicillin therapy according to CDC guidelines. Nine patients were misdiagnosed before presenting to our center and the delay in treatment with penicillin was associated with poor final visual outcomes (P<0.05). Conclusions. In our series, both male and female were almost equally affected and coinfection of syphilis with human immunodeficiency virus was uncommon. All patients in this study had posterior involvement and the most common manifestations were retinal vasculitis and papillitis. Syphilis should be considered as an important differential diagnosis especially for posterior uveitis and panuveitis. Early diagnosis and appropriate treatment are important for visual prognosis.http://dx.doi.org/10.1155/2016/2797028 |
| spellingShingle | Rui Zhang Jiang Qian Jie Guo Yifei Yuan Kang Xue Han Yue Ling Chen Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population Journal of Ophthalmology |
| title | Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population |
| title_full | Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population |
| title_fullStr | Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population |
| title_full_unstemmed | Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population |
| title_short | Clinical Manifestations and Treatment Outcomes of Syphilitic Uveitis in a Chinese Population |
| title_sort | clinical manifestations and treatment outcomes of syphilitic uveitis in a chinese population |
| url | http://dx.doi.org/10.1155/2016/2797028 |
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