Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives
Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing comm...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/4358453 |
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| _version_ | 1832554364819996672 |
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| author | Tanveer MahamadAlli Shaikh Habtamu Debebe |
| author_facet | Tanveer MahamadAlli Shaikh Habtamu Debebe |
| author_sort | Tanveer MahamadAlli Shaikh |
| collection | DOAJ |
| description | Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol. |
| format | Article |
| id | doaj-art-76c58dc4f2164eaca628def46af78311 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-76c58dc4f2164eaca628def46af783112025-02-03T05:51:45ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/43584534358453Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole DerivativesTanveer MahamadAlli Shaikh0Habtamu Debebe1Department of Chemistry, College of Natural and Computational Sciences, Mekelle University, Mekelle, EthiopiaDepartment of Chemistry, College of Natural and Computational Sciences, Mekelle University, Mekelle, EthiopiaIndole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.http://dx.doi.org/10.1155/2020/4358453 |
| spellingShingle | Tanveer MahamadAlli Shaikh Habtamu Debebe Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives Journal of Chemistry |
| title | Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives |
| title_full | Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives |
| title_fullStr | Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives |
| title_full_unstemmed | Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives |
| title_short | Synthesis and Evaluation of Antimicrobial Activities of Novel N-Substituted Indole Derivatives |
| title_sort | synthesis and evaluation of antimicrobial activities of novel n substituted indole derivatives |
| url | http://dx.doi.org/10.1155/2020/4358453 |
| work_keys_str_mv | AT tanveermahamadallishaikh synthesisandevaluationofantimicrobialactivitiesofnovelnsubstitutedindolederivatives AT habtamudebebe synthesisandevaluationofantimicrobialactivitiesofnovelnsubstitutedindolederivatives |