Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study
Objectives: Differences in oncological outcomes between conservative and surgical treatments for anastomotic leakage (AL) in patients undergoing colorectal cancer surgery remain unclear. Methods: From July 2011 to June 2020, 385 patients underwent curative resection with double-stapling anastomosis...
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| Format: | Article |
| Language: | English |
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The Japan Society of Coloproctology
2025-01-01
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| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-005/_pdf/-char/en |
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| _version_ | 1832584933701320704 |
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| author | Junichi Sakamoto Atsuko Tsutsui Chie Hagiwara Go Wakabayashi |
| author_facet | Junichi Sakamoto Atsuko Tsutsui Chie Hagiwara Go Wakabayashi |
| author_sort | Junichi Sakamoto |
| collection | DOAJ |
| description | Objectives: Differences in oncological outcomes between conservative and surgical treatments for anastomotic leakage (AL) in patients undergoing colorectal cancer surgery remain unclear.
Methods: From July 2011 to June 2020, 385 patients underwent curative resection with double-stapling anastomosis for left-sided colon and rectal cancers. Among them, 33 patients who experienced AL were retrospectively evaluated and categorized into two groups: conservative (n = 20) and surgical (n = 13). In the surgical group, abdominal lavage using a sufficient amount of normal saline was performed during reoperation. The primary endpoint was the 3-year cumulative incidence of local recurrence (LR).
Results: Seven (21.2%) patients in the conservative group experienced LR, while none in the surgical group. Survival analysis indicated no differences in overall and recurrent-free survival. However, the 3-year cumulative incidence of LR was significantly lower in the surgical group than in the conservative group (0% versus 31.3%, p=0.045).
Conclusions: Differences in AL management were associated with oncological outcomes, specifically a decreased LR. Therefore, surgeons should consider our findings when determining the most appropriate AL treatment to improve oncological outcomes. |
| format | Article |
| id | doaj-art-76bccb3d20014ad6b3b3ea054a2b325e |
| institution | Kabale University |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-76bccb3d20014ad6b3b3ea054a2b325e2025-01-27T10:02:40ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-01-0191616810.23922/jarc.2024-0052024-005Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective StudyJunichi Sakamoto0Atsuko Tsutsui1Chie Hagiwara2Go Wakabayashi3Department of Surgery, Ageo Central General HospitalDepartment of Surgery, Ageo Central General HospitalDepartment of Surgery, Ageo Central General HospitalDepartment of Surgery, Ageo Central General HospitalObjectives: Differences in oncological outcomes between conservative and surgical treatments for anastomotic leakage (AL) in patients undergoing colorectal cancer surgery remain unclear. Methods: From July 2011 to June 2020, 385 patients underwent curative resection with double-stapling anastomosis for left-sided colon and rectal cancers. Among them, 33 patients who experienced AL were retrospectively evaluated and categorized into two groups: conservative (n = 20) and surgical (n = 13). In the surgical group, abdominal lavage using a sufficient amount of normal saline was performed during reoperation. The primary endpoint was the 3-year cumulative incidence of local recurrence (LR). Results: Seven (21.2%) patients in the conservative group experienced LR, while none in the surgical group. Survival analysis indicated no differences in overall and recurrent-free survival. However, the 3-year cumulative incidence of LR was significantly lower in the surgical group than in the conservative group (0% versus 31.3%, p=0.045). Conclusions: Differences in AL management were associated with oncological outcomes, specifically a decreased LR. Therefore, surgeons should consider our findings when determining the most appropriate AL treatment to improve oncological outcomes.https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-005/_pdf/-char/enanastomotic leakagecolorectal cancerlocal recurrenceoncological outcome |
| spellingShingle | Junichi Sakamoto Atsuko Tsutsui Chie Hagiwara Go Wakabayashi Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study Journal of the Anus, Rectum and Colon anastomotic leakage colorectal cancer local recurrence oncological outcome |
| title | Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study |
| title_full | Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study |
| title_fullStr | Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study |
| title_full_unstemmed | Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study |
| title_short | Oncologic Impact of Conservative Treatment Compared with Surgical Treatment of Anastomotic Leakage Following Colorectal Cancer Surgery: A Retrospective Study |
| title_sort | oncologic impact of conservative treatment compared with surgical treatment of anastomotic leakage following colorectal cancer surgery a retrospective study |
| topic | anastomotic leakage colorectal cancer local recurrence oncological outcome |
| url | https://www.jstage.jst.go.jp/article/jarc/9/1/9_2024-005/_pdf/-char/en |
| work_keys_str_mv | AT junichisakamoto oncologicimpactofconservativetreatmentcomparedwithsurgicaltreatmentofanastomoticleakagefollowingcolorectalcancersurgeryaretrospectivestudy AT atsukotsutsui oncologicimpactofconservativetreatmentcomparedwithsurgicaltreatmentofanastomoticleakagefollowingcolorectalcancersurgeryaretrospectivestudy AT chiehagiwara oncologicimpactofconservativetreatmentcomparedwithsurgicaltreatmentofanastomoticleakagefollowingcolorectalcancersurgeryaretrospectivestudy AT gowakabayashi oncologicimpactofconservativetreatmentcomparedwithsurgicaltreatmentofanastomoticleakagefollowingcolorectalcancersurgeryaretrospectivestudy |