Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches
Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, an...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cell Adhesion & Migration |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19336918.2024.2335682 |
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| _version_ | 1850129018263699456 |
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| author | Canxuan Li Yunfei Xiao Jianqiu Kong Cong Lai Zhiliang Chen Zhuohang Li Weibin Xie |
| author_facet | Canxuan Li Yunfei Xiao Jianqiu Kong Cong Lai Zhiliang Chen Zhuohang Li Weibin Xie |
| author_sort | Canxuan Li |
| collection | DOAJ |
| description | Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1’s involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis. |
| format | Article |
| id | doaj-art-76aff67239cb44c5b94de401e77f96cf |
| institution | OA Journals |
| issn | 1933-6918 1933-6926 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cell Adhesion & Migration |
| spelling | doaj-art-76aff67239cb44c5b94de401e77f96cf2025-08-20T02:33:07ZengTaylor & Francis GroupCell Adhesion & Migration1933-69181933-69262024-12-0118111710.1080/19336918.2024.2335682Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approachesCanxuan Li0Yunfei Xiao1Jianqiu Kong2Cong Lai3Zhiliang Chen4Zhuohang Li5Weibin Xie6Department of Urology, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaDepartment of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. ChinaMolecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1’s involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.https://www.tandfonline.com/doi/10.1080/19336918.2024.2335682Bioinformaticsimmune pathwaysMICAL1pan-cancertumor immune microenvironment |
| spellingShingle | Canxuan Li Yunfei Xiao Jianqiu Kong Cong Lai Zhiliang Chen Zhuohang Li Weibin Xie Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches Cell Adhesion & Migration Bioinformatics immune pathways MICAL1 pan-cancer tumor immune microenvironment |
| title | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| title_full | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| title_fullStr | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| title_full_unstemmed | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| title_short | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
| title_sort | elucidating the role of mical1 in pan cancer using integrated bioinformatics and experimental approaches |
| topic | Bioinformatics immune pathways MICAL1 pan-cancer tumor immune microenvironment |
| url | https://www.tandfonline.com/doi/10.1080/19336918.2024.2335682 |
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