The Effect of Different Glycaemic States on Renal Transplant Outcomes
Background. Optimal glycaemic targets following transplantation are unknown. Understanding the impact of DM and posttransplant diabetes mellitus (PTDM) may improve patient and graft survival in transplant recipients. Aim. To determine the perioperative and one-year outcomes after renal transplantati...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8735782 |
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| author | Angela Sheu Barbara Depczynski Anthony J. O’Sullivan Grant Luxton George Mangos |
| author_facet | Angela Sheu Barbara Depczynski Anthony J. O’Sullivan Grant Luxton George Mangos |
| author_sort | Angela Sheu |
| collection | DOAJ |
| description | Background. Optimal glycaemic targets following transplantation are unknown. Understanding the impact of DM and posttransplant diabetes mellitus (PTDM) may improve patient and graft survival in transplant recipients. Aim. To determine the perioperative and one-year outcomes after renal transplantation and whether these outcomes are affected by preexisting DM, PTDM, or glycaemia during transplant admission. Method. Adult recipients of renal transplants from a single centre over 5.5 years were retrospectively reviewed. Measured outcomes during transplant admission included glycaemia and complications (infective complications, acute rejection, and return to dialysis) and, at 12 months, glycaemic control and complications (cardiovascular complication, graft failure). Results. Of 148 patients analysed, 29 (19.6%) had DM and 27 (18.2%) developed PTDM. Following transplantation, glucose levels were higher in patients with DM and PTDM. DM patients had a longer hospital stay, had more infections, and were more likely return to dialysis. PTDM patients had increased rates of acute rejection and return to dialysis. At 1 year after transplant, there were more cardiovascular complications in DM patients compared to those without DM. Conclusions. Compared to patients without DM, patients with DM or PTDM are more likely to suffer from complications perioperatively and at 12 months. Perioperative glycaemia is associated with graft function and may be a modifiable risk. |
| format | Article |
| id | doaj-art-76a627f866334b42ac8e73fd2ef15cfa |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-76a627f866334b42ac8e73fd2ef15cfa2025-02-03T07:24:36ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/87357828735782The Effect of Different Glycaemic States on Renal Transplant OutcomesAngela Sheu0Barbara Depczynski1Anthony J. O’Sullivan2Grant Luxton3George Mangos4Department of Endocrinology, Prince of Wales Hospital, Randwick, Sydney, NSW, AustraliaDepartment of Endocrinology, Prince of Wales Hospital, Randwick, Sydney, NSW, AustraliaDepartment of Endocrinology, St George Hospital, Kogarah, Sydney, NSW, AustraliaPrince of Wales Clinical School, UNSW Medicine, Randwick, Sydney, NSW, AustraliaSt George & Sutherland Clinical School, UNSW Medicine, Kogarah, Sydney, NSW, AustraliaBackground. Optimal glycaemic targets following transplantation are unknown. Understanding the impact of DM and posttransplant diabetes mellitus (PTDM) may improve patient and graft survival in transplant recipients. Aim. To determine the perioperative and one-year outcomes after renal transplantation and whether these outcomes are affected by preexisting DM, PTDM, or glycaemia during transplant admission. Method. Adult recipients of renal transplants from a single centre over 5.5 years were retrospectively reviewed. Measured outcomes during transplant admission included glycaemia and complications (infective complications, acute rejection, and return to dialysis) and, at 12 months, glycaemic control and complications (cardiovascular complication, graft failure). Results. Of 148 patients analysed, 29 (19.6%) had DM and 27 (18.2%) developed PTDM. Following transplantation, glucose levels were higher in patients with DM and PTDM. DM patients had a longer hospital stay, had more infections, and were more likely return to dialysis. PTDM patients had increased rates of acute rejection and return to dialysis. At 1 year after transplant, there were more cardiovascular complications in DM patients compared to those without DM. Conclusions. Compared to patients without DM, patients with DM or PTDM are more likely to suffer from complications perioperatively and at 12 months. Perioperative glycaemia is associated with graft function and may be a modifiable risk.http://dx.doi.org/10.1155/2016/8735782 |
| spellingShingle | Angela Sheu Barbara Depczynski Anthony J. O’Sullivan Grant Luxton George Mangos The Effect of Different Glycaemic States on Renal Transplant Outcomes Journal of Diabetes Research |
| title | The Effect of Different Glycaemic States on Renal Transplant Outcomes |
| title_full | The Effect of Different Glycaemic States on Renal Transplant Outcomes |
| title_fullStr | The Effect of Different Glycaemic States on Renal Transplant Outcomes |
| title_full_unstemmed | The Effect of Different Glycaemic States on Renal Transplant Outcomes |
| title_short | The Effect of Different Glycaemic States on Renal Transplant Outcomes |
| title_sort | effect of different glycaemic states on renal transplant outcomes |
| url | http://dx.doi.org/10.1155/2016/8735782 |
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