Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione
Indane-1, 3-dione (1) synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide (3) which on tre...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2007/865470 |
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| author | D. Giles M. S. Prakash K. V. Ramseshu |
| author_facet | D. Giles M. S. Prakash K. V. Ramseshu |
| author_sort | D. Giles |
| collection | DOAJ |
| description | Indane-1, 3-dione (1) synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide (3) which on treatment with 1 gave 2-substituted thio phenyl derivatives (4a-g) of 1. The synthesized compounds were characterized on the basis of I.R and H1NMR. Synthesized compounds (4a-g) were investigated for their anticoagulant, analgesic, anti-inflammatory, antifungal, antibacterial and anticancer activities. Some of the synthesized compounds have shown moderate activities. |
| format | Article |
| id | doaj-art-768f1ad042c9406a86f867690c965e69 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-768f1ad042c9406a86f867690c965e692025-02-03T01:28:48ZengWileyE-Journal of Chemistry0973-49452090-98102007-01-014342843310.1155/2007/865470Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-DioneD. Giles0M. S. Prakash1K. V. Ramseshu2K. M. College of Pharmacy, Madurai, Tamilnadu, IndiaK. M. College of Pharmacy, Madurai, Tamilnadu, IndiaK. M. College of Pharmacy, Madurai, Tamilnadu, IndiaIndane-1, 3-dione (1) synthesized by condensation of diethyl phthalate and ethyl acetate in presence of sodium ethoxide gave sodium salt of ester derivative, which on neutralization in presence of sulphuric acid afford 1. Various thiols where converted to their respective disulphide (3) which on treatment with 1 gave 2-substituted thio phenyl derivatives (4a-g) of 1. The synthesized compounds were characterized on the basis of I.R and H1NMR. Synthesized compounds (4a-g) were investigated for their anticoagulant, analgesic, anti-inflammatory, antifungal, antibacterial and anticancer activities. Some of the synthesized compounds have shown moderate activities.http://dx.doi.org/10.1155/2007/865470 |
| spellingShingle | D. Giles M. S. Prakash K. V. Ramseshu Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione E-Journal of Chemistry |
| title | Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione |
| title_full | Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione |
| title_fullStr | Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione |
| title_full_unstemmed | Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione |
| title_short | Synthesis and Biological Evaluation of Substituted Thiophenyl Derivatives of Indane-1, 3-Dione |
| title_sort | synthesis and biological evaluation of substituted thiophenyl derivatives of indane 1 3 dione |
| url | http://dx.doi.org/10.1155/2007/865470 |
| work_keys_str_mv | AT dgiles synthesisandbiologicalevaluationofsubstitutedthiophenylderivativesofindane13dione AT msprakash synthesisandbiologicalevaluationofsubstitutedthiophenylderivativesofindane13dione AT kvramseshu synthesisandbiologicalevaluationofsubstitutedthiophenylderivativesofindane13dione |