Ketogenic diets and Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid β-peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypomet...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2017-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016301355 |
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| author | Klaus W. Lange Katharina M. Lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya Joachim Hauser |
| author_facet | Klaus W. Lange Katharina M. Lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya Joachim Hauser |
| author_sort | Klaus W. Lange |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid β-peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD. The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention. This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired. The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. Both the direct administration of ketone bodies and the use of high-fat, low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients. The mechanism underlying the efficacy of ketogenic diets remains unclear, but some evidence points to the normalization of aberrant energy metabolism. At present there is only limited evidence of the usefulness of ketogenic diets in AD. However, this dietary approach seems to be promising and deserves further clinical investigations. |
| format | Article |
| id | doaj-art-768e1b0bb45c47d9a6d3b5a70c847d5e |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-768e1b0bb45c47d9a6d3b5a70c847d5e2025-02-03T06:52:27ZengTsinghua University PressFood Science and Human Wellness2213-45302017-03-01611910.1016/j.fshw.2016.10.003Ketogenic diets and Alzheimer’s diseaseKlaus W. Lange0Katharina M. Lange1Ewelina Makulska-Gertruda2Yukiko Nakamura3Andreas Reissmann4Shigehiko Kanaya5Joachim Hauser6Department of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Psychology, University of Winchester, UKDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyGraduate School of Information Science, Nara Institute of Science and Technology, JapanDepartment of Experimental Psychology, University of Regensburg, 93040 Regensburg, GermanyAlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by decline in cognitive functions and associated with the neuropathological hallmarks of amyloid β-peptide plaques and neurofibrillary tangles. Cerebral glucose uptake and metabolism deteriorate in AD and this hypometabolism precedes the onset of clinical signs in AD. The early decline in brain glucose metabolism in AD has become a potential target for therapeutic intervention. This has led to investigations assessing the supplementation of the normal glucose supply with ketone bodies which are produced by the body during glucose deprivation and can be metabolized by the brain when glucose utilization is impaired. The present review provides a synopsis of preclinical studies and clinical trials assessing the efficacy of ketogenic diets in the treatment of AD. Both the direct administration of ketone bodies and the use of high-fat, low-carbohydrate ketogenic diets have been shown to be efficacious in animal models of AD and clinical trials with AD patients. The mechanism underlying the efficacy of ketogenic diets remains unclear, but some evidence points to the normalization of aberrant energy metabolism. At present there is only limited evidence of the usefulness of ketogenic diets in AD. However, this dietary approach seems to be promising and deserves further clinical investigations.http://www.sciencedirect.com/science/article/pii/S2213453016301355Alzheimer’s diseaseKetone bodiesKetogenic dietTherapy |
| spellingShingle | Klaus W. Lange Katharina M. Lange Ewelina Makulska-Gertruda Yukiko Nakamura Andreas Reissmann Shigehiko Kanaya Joachim Hauser Ketogenic diets and Alzheimer’s disease Food Science and Human Wellness Alzheimer’s disease Ketone bodies Ketogenic diet Therapy |
| title | Ketogenic diets and Alzheimer’s disease |
| title_full | Ketogenic diets and Alzheimer’s disease |
| title_fullStr | Ketogenic diets and Alzheimer’s disease |
| title_full_unstemmed | Ketogenic diets and Alzheimer’s disease |
| title_short | Ketogenic diets and Alzheimer’s disease |
| title_sort | ketogenic diets and alzheimer s disease |
| topic | Alzheimer’s disease Ketone bodies Ketogenic diet Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016301355 |
| work_keys_str_mv | AT klauswlange ketogenicdietsandalzheimersdisease AT katharinamlange ketogenicdietsandalzheimersdisease AT ewelinamakulskagertruda ketogenicdietsandalzheimersdisease AT yukikonakamura ketogenicdietsandalzheimersdisease AT andreasreissmann ketogenicdietsandalzheimersdisease AT shigehikokanaya ketogenicdietsandalzheimersdisease AT joachimhauser ketogenicdietsandalzheimersdisease |