Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies
Parkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects. Although most PD cases are sporadic, several genes are associated with rare familial forms o...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.4061/2011/520640 |
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| _version_ | 1832549240606294016 |
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| author | Verónica Muñoz-Soriano Nuria Paricio |
| author_facet | Verónica Muñoz-Soriano Nuria Paricio |
| author_sort | Verónica Muñoz-Soriano |
| collection | DOAJ |
| description | Parkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects. Although most PD cases are sporadic, several genes are associated with rare familial forms of the disease. Analyses of their function have provided important insights into the disease process, demonstrating that three types of cellular defects are mainly involved in the formation and/or progression of PD: abnormal protein aggregation, oxidative damage, and mitochondrial dysfunction. These studies have been mainly performed in PD models created in mice, fruit flies, and worms. Among them, Drosophila has emerged as a very valuable model organism in the study of either toxin-induced or genetically linked PD. Indeed, many of the existing fly PD models exhibit key features of the disease and have been instrumental to discover pathways relevant for PD pathogenesis, which could facilitate the development of therapeutic strategies. |
| format | Article |
| id | doaj-art-767cf5f6714c465e871e0ab4c0d59496 |
| institution | Kabale University |
| issn | 2042-0080 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-767cf5f6714c465e871e0ab4c0d594962025-02-03T06:11:43ZengWileyParkinson's Disease2042-00802011-01-01201110.4061/2011/520640520640Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic StrategiesVerónica Muñoz-Soriano0Nuria Paricio1Departamento de Genética, Facultad CC Biológicas, Universidad de Valencia, Avenida Dr. Moliner 50, 46100 Burjasot, SpainDepartamento de Genética, Facultad CC Biológicas, Universidad de Valencia, Avenida Dr. Moliner 50, 46100 Burjasot, SpainParkinson's disease (PD) is the second most common neurodegenerative disorder and is mainly characterized by the selective and progressive loss of dopaminergic neurons, accompanied by locomotor defects. Although most PD cases are sporadic, several genes are associated with rare familial forms of the disease. Analyses of their function have provided important insights into the disease process, demonstrating that three types of cellular defects are mainly involved in the formation and/or progression of PD: abnormal protein aggregation, oxidative damage, and mitochondrial dysfunction. These studies have been mainly performed in PD models created in mice, fruit flies, and worms. Among them, Drosophila has emerged as a very valuable model organism in the study of either toxin-induced or genetically linked PD. Indeed, many of the existing fly PD models exhibit key features of the disease and have been instrumental to discover pathways relevant for PD pathogenesis, which could facilitate the development of therapeutic strategies.http://dx.doi.org/10.4061/2011/520640 |
| spellingShingle | Verónica Muñoz-Soriano Nuria Paricio Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies Parkinson's Disease |
| title | Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies |
| title_full | Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies |
| title_fullStr | Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies |
| title_full_unstemmed | Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies |
| title_short | Drosophila Models of Parkinson's Disease: Discovering Relevant Pathways and Novel Therapeutic Strategies |
| title_sort | drosophila models of parkinson s disease discovering relevant pathways and novel therapeutic strategies |
| url | http://dx.doi.org/10.4061/2011/520640 |
| work_keys_str_mv | AT veronicamunozsoriano drosophilamodelsofparkinsonsdiseasediscoveringrelevantpathwaysandnoveltherapeuticstrategies AT nuriaparicio drosophilamodelsofparkinsonsdiseasediscoveringrelevantpathwaysandnoveltherapeuticstrategies |