Liver steatosis in brain death donors
Aim. To study the frequency of fatty hepatosis in liver biopsies of consecutive brain death donors before cold preservation. Materials and methods. Liver biopsies (before cold preservation) of 300 consecutive donors with brain death were studied. Histological preparations were stained with hematoxyl...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2021-04-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1309 |
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| author | D. V. Voronov M. G. Minina A. K. Chomaev I. M. Iljinsky O. M. Tsirulnikova |
| author_facet | D. V. Voronov M. G. Minina A. K. Chomaev I. M. Iljinsky O. M. Tsirulnikova |
| author_sort | D. V. Voronov |
| collection | DOAJ |
| description | Aim. To study the frequency of fatty hepatosis in liver biopsies of consecutive brain death donors before cold preservation. Materials and methods. Liver biopsies (before cold preservation) of 300 consecutive donors with brain death were studied. Histological preparations were stained with hematoxylin and eosin, and tricolor Masson staining was performed. Results. The frequency of different degrees of fat hepatosis in men and women did not differ significantly (>0.05). Fat dystrophy of hepatocytes was absent in more than half of the cases (n = 182; 60.7%). A slight degree of fatty degeneration was diagnosed in 57 (19,0%) donors. In total, 239 (79.7%) donor livers were absolutely suitable for transplantation. Moderate degree of steatosis, which is associated with early biliary complications, was detected in 18 (6.0%) cases, and severe degree, which is a contraindication to the use of the organ for transplantation, was detected in 43 (14.3%) cases. Conclusion. Before cold preservation, liver from brain death donors is relatively rarely unsuitable for transplantation. |
| format | Article |
| id | doaj-art-765fa30f378a4a65aad3d65c419d9d28 |
| institution | DOAJ |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-765fa30f378a4a65aad3d65c419d9d282025-08-20T03:21:06ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912021-04-0123181410.15825/1995-1191-2021-1-8-14950Liver steatosis in brain death donorsD. V. Voronov0M. G. Minina1A. K. Chomaev2I. M. Iljinsky3O. M. Tsirulnikova4Botkin City Clinical Hospital , Moscow coordinating center of organ donationBotkin City Clinical Hospital , Moscow coordinating center of organ donationShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityAim. To study the frequency of fatty hepatosis in liver biopsies of consecutive brain death donors before cold preservation. Materials and methods. Liver biopsies (before cold preservation) of 300 consecutive donors with brain death were studied. Histological preparations were stained with hematoxylin and eosin, and tricolor Masson staining was performed. Results. The frequency of different degrees of fat hepatosis in men and women did not differ significantly (>0.05). Fat dystrophy of hepatocytes was absent in more than half of the cases (n = 182; 60.7%). A slight degree of fatty degeneration was diagnosed in 57 (19,0%) donors. In total, 239 (79.7%) donor livers were absolutely suitable for transplantation. Moderate degree of steatosis, which is associated with early biliary complications, was detected in 18 (6.0%) cases, and severe degree, which is a contraindication to the use of the organ for transplantation, was detected in 43 (14.3%) cases. Conclusion. Before cold preservation, liver from brain death donors is relatively rarely unsuitable for transplantation.https://journal.transpl.ru/vtio/article/view/1309donor liverbiopsysteatosis |
| spellingShingle | D. V. Voronov M. G. Minina A. K. Chomaev I. M. Iljinsky O. M. Tsirulnikova Liver steatosis in brain death donors Вестник трансплантологии и искусственных органов donor liver biopsy steatosis |
| title | Liver steatosis in brain death donors |
| title_full | Liver steatosis in brain death donors |
| title_fullStr | Liver steatosis in brain death donors |
| title_full_unstemmed | Liver steatosis in brain death donors |
| title_short | Liver steatosis in brain death donors |
| title_sort | liver steatosis in brain death donors |
| topic | donor liver biopsy steatosis |
| url | https://journal.transpl.ru/vtio/article/view/1309 |
| work_keys_str_mv | AT dvvoronov liversteatosisinbraindeathdonors AT mgminina liversteatosisinbraindeathdonors AT akchomaev liversteatosisinbraindeathdonors AT imiljinsky liversteatosisinbraindeathdonors AT omtsirulnikova liversteatosisinbraindeathdonors |