High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis
Prenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring. Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation. This study inves...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/368475 |
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| author | Minji Park Yuri Choi Hyeonhae Choi Ju-Yearn Yim Jaesook Roh |
| author_facet | Minji Park Yuri Choi Hyeonhae Choi Ju-Yearn Yim Jaesook Roh |
| author_sort | Minji Park |
| collection | DOAJ |
| description | Prenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring. Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation. This study investigated the impact of high doses of caffeine on the testes of prepubertal male rats. A total of 45 immature male rats were divided randomly into three groups: a control group and 2 groups fed 120 and 180 mg/kg/day of caffeine, respectively, via the stomach for 4 weeks. Caffeine caused a significant decrease in body weight gain, accompanied by proportional decreases in lean body mass and body fat. The caffeine-fed animals had smaller and lighter testes than those of the control that were accompanied by negative influences on the histologic parameters of the testes. In addition, stimulated-testosterone ex vivo production was reduced in Leydig cells retrieved from the caffeine-fed animals. Our results demonstrate that peripubertal caffeine consumption can interfere with the maturation and function of the testis, possibly by interrupting endogenous testosterone secretion and reducing the sensitivity of Leydig cells to gonadotrophic stimulation. In addition, we confirmed that pubertal administration of caffeine reduced testis growth and altered testis histomorphology. |
| format | Article |
| id | doaj-art-765e01267d654341bbcc3d5a5fc65349 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-765e01267d654341bbcc3d5a5fc653492025-02-03T01:25:55ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/368475368475High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the TestisMinji Park0Yuri Choi1Hyeonhae Choi2Ju-Yearn Yim3Jaesook Roh4Laboratory of Reproductive Endocrinology, Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of KoreaLaboratory of Reproductive Endocrinology, Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of KoreaLaboratory of Reproductive Endocrinology, Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of KoreaLaboratory of Reproductive Endocrinology, Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of KoreaLaboratory of Reproductive Endocrinology, Department of Anatomy & Cell Biology, College of Medicine, Hanyang University, Seoul 133-791, Republic of KoreaPrenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring. Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation. This study investigated the impact of high doses of caffeine on the testes of prepubertal male rats. A total of 45 immature male rats were divided randomly into three groups: a control group and 2 groups fed 120 and 180 mg/kg/day of caffeine, respectively, via the stomach for 4 weeks. Caffeine caused a significant decrease in body weight gain, accompanied by proportional decreases in lean body mass and body fat. The caffeine-fed animals had smaller and lighter testes than those of the control that were accompanied by negative influences on the histologic parameters of the testes. In addition, stimulated-testosterone ex vivo production was reduced in Leydig cells retrieved from the caffeine-fed animals. Our results demonstrate that peripubertal caffeine consumption can interfere with the maturation and function of the testis, possibly by interrupting endogenous testosterone secretion and reducing the sensitivity of Leydig cells to gonadotrophic stimulation. In addition, we confirmed that pubertal administration of caffeine reduced testis growth and altered testis histomorphology.http://dx.doi.org/10.1155/2015/368475 |
| spellingShingle | Minji Park Yuri Choi Hyeonhae Choi Ju-Yearn Yim Jaesook Roh High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis International Journal of Endocrinology |
| title | High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis |
| title_full | High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis |
| title_fullStr | High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis |
| title_full_unstemmed | High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis |
| title_short | High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis |
| title_sort | high doses of caffeine during the peripubertal period in the rat impair the growth and function of the testis |
| url | http://dx.doi.org/10.1155/2015/368475 |
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