Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders
Neurodevelopmental disorders group conditions in which the growth and development of the brain is altered. This can damage both the neurocognitive and behavioral spheres such as the development of language, emotions, behavior, self-control, learning and memory, and also motor functions. They include...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Spanish |
| Published: |
Universidad de las Ciencias Médicas de Cienfuegos
2024-07-01
|
| Series: | Revista Finlay |
| Subjects: | |
| Online Access: | https://revfinlay.sld.cu/index.php/finlay/article/view/1410 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832577396922908672 |
|---|---|
| author | José Ignacio Lao Villadóniga |
| author_facet | José Ignacio Lao Villadóniga |
| author_sort | José Ignacio Lao Villadóniga |
| collection | DOAJ |
| description | Neurodevelopmental disorders group conditions in which the growth and development of the brain is altered. This can damage both the neurocognitive and behavioral spheres such as the development of language, emotions, behavior, self-control, learning and memory, and also motor functions. They include attention deficit and hyperactivity disorders, autism spectrum disorders, communication problems, intellectual development problems, as well as various specific learning disorders and various motor disorders. They begin early in a child's development and can continue throughout life. In each one, a wide heterogeneity is observed in terms of manifestations, evolution and their response to support interventions and treatments. In this article, we consider the impact that the interaction of genetic polymorphisms in several genes, known as epistasis, can have within the main etiopathogenic pathways to be taken into account in these cases and how these interactions affect each “facilitating” genotype. It interacts with the rest of the factors, such as non-genetic ones. |
| format | Article |
| id | doaj-art-765c5409c56d4071a4a1507830482a0e |
| institution | Kabale University |
| issn | 2221-2434 |
| language | Spanish |
| publishDate | 2024-07-01 |
| publisher | Universidad de las Ciencias Médicas de Cienfuegos |
| record_format | Article |
| series | Revista Finlay |
| spelling | doaj-art-765c5409c56d4071a4a1507830482a0e2025-01-30T21:22:03ZspaUniversidad de las Ciencias Médicas de CienfuegosRevista Finlay2221-24342024-07-01143301311720Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental DisordersJosé Ignacio Lao Villadóniga0Instituto de Formación Continuada de la Universidad de Barcelona. Sociedad Española de Genética Clínica y Dismorfología. Sociedad Española de Medicina Antienvejecimiento y Longevidad. Director Médico en Genomic Genetics International. Barcelona. España.Neurodevelopmental disorders group conditions in which the growth and development of the brain is altered. This can damage both the neurocognitive and behavioral spheres such as the development of language, emotions, behavior, self-control, learning and memory, and also motor functions. They include attention deficit and hyperactivity disorders, autism spectrum disorders, communication problems, intellectual development problems, as well as various specific learning disorders and various motor disorders. They begin early in a child's development and can continue throughout life. In each one, a wide heterogeneity is observed in terms of manifestations, evolution and their response to support interventions and treatments. In this article, we consider the impact that the interaction of genetic polymorphisms in several genes, known as epistasis, can have within the main etiopathogenic pathways to be taken into account in these cases and how these interactions affect each “facilitating” genotype. It interacts with the rest of the factors, such as non-genetic ones.https://revfinlay.sld.cu/index.php/finlay/article/view/1410trastornos del neurodesarrollotrastorno del espectro autistagenéticagenómicaepistasis genéticapolimorfismo genéticogenes modificadores |
| spellingShingle | José Ignacio Lao Villadóniga Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders Revista Finlay trastornos del neurodesarrollo trastorno del espectro autista genética genómica epistasis genética polimorfismo genético genes modificadores |
| title | Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders |
| title_full | Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders |
| title_fullStr | Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders |
| title_full_unstemmed | Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders |
| title_short | Epistasis in Modifying Genes: Key Factor to Differentiate Clinical Subtypes in Neurodevelopmental Disorders |
| title_sort | epistasis in modifying genes key factor to differentiate clinical subtypes in neurodevelopmental disorders |
| topic | trastornos del neurodesarrollo trastorno del espectro autista genética genómica epistasis genética polimorfismo genético genes modificadores |
| url | https://revfinlay.sld.cu/index.php/finlay/article/view/1410 |
| work_keys_str_mv | AT joseignaciolaovilladoniga epistasisinmodifyinggeneskeyfactortodifferentiateclinicalsubtypesinneurodevelopmentaldisorders |