Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer
Breast cancer (BC), a globally prevalent malignancy, shows significant variability in incidence across different geographical regions. In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer gra...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | The Breast Journal |
| Online Access: | http://dx.doi.org/10.1155/2024/3461694 |
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| _version_ | 1832544758062383104 |
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| author | Negar Soltani Irdmusa Haniyeh Bashi Zadeh Fakhar Masoumeh Heshmati Mohammad Esmaiel Akbari Sara Rahimi |
| author_facet | Negar Soltani Irdmusa Haniyeh Bashi Zadeh Fakhar Masoumeh Heshmati Mohammad Esmaiel Akbari Sara Rahimi |
| author_sort | Negar Soltani Irdmusa |
| collection | DOAJ |
| description | Breast cancer (BC), a globally prevalent malignancy, shows significant variability in incidence across different geographical regions. In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer grades. Our research, conducted at the Baqiyat Elah Hospital in Tehran in 2021, involved collecting blood and serum samples from BC patients. These samples underwent BRCA1 gene expression analysis and CA15-3 tumor marker assessment. Using the AJCC grading system, we categorized BC patients into various grades. Our findings revealed that BRCA1 gene expression was present in 28.57% of patients, while 71.43% showed negative expression. Both BRCA1 expression and CA15-3 levels significantly increased with advanced cancer stages (P<0.001). These results suggest the potential utility of BRCA1 gene expression and CA15-3 tumor marker assessment in BC prognosis and management, particularly concerning staging and disease progression. This study provides valuable insights into the biology of BC and the development of prognostic markers for improved patient outcomes. |
| format | Article |
| id | doaj-art-7648a273101942e3829fdfd4d8a15755 |
| institution | Kabale University |
| issn | 1524-4741 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Breast Journal |
| spelling | doaj-art-7648a273101942e3829fdfd4d8a157552025-02-03T09:57:54ZengWileyThe Breast Journal1524-47412024-01-01202410.1155/2024/3461694Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast CancerNegar Soltani Irdmusa0Haniyeh Bashi Zadeh Fakhar1Masoumeh Heshmati2Mohammad Esmaiel Akbari3Sara Rahimi4Department of Cell and Molecular SciencesDepartment of Laboratory ScienceDepartment of Cell and Molecular SciencesCancer Research CenterDepartment of Cell and Molecular SciencesBreast cancer (BC), a globally prevalent malignancy, shows significant variability in incidence across different geographical regions. In this study, we examined the expression of the tumor suppressor gene BRCA1 and the tumor marker CA15-3 in women diagnosed with BC, focusing on different cancer grades. Our research, conducted at the Baqiyat Elah Hospital in Tehran in 2021, involved collecting blood and serum samples from BC patients. These samples underwent BRCA1 gene expression analysis and CA15-3 tumor marker assessment. Using the AJCC grading system, we categorized BC patients into various grades. Our findings revealed that BRCA1 gene expression was present in 28.57% of patients, while 71.43% showed negative expression. Both BRCA1 expression and CA15-3 levels significantly increased with advanced cancer stages (P<0.001). These results suggest the potential utility of BRCA1 gene expression and CA15-3 tumor marker assessment in BC prognosis and management, particularly concerning staging and disease progression. This study provides valuable insights into the biology of BC and the development of prognostic markers for improved patient outcomes.http://dx.doi.org/10.1155/2024/3461694 |
| spellingShingle | Negar Soltani Irdmusa Haniyeh Bashi Zadeh Fakhar Masoumeh Heshmati Mohammad Esmaiel Akbari Sara Rahimi Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer The Breast Journal |
| title | Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer |
| title_full | Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer |
| title_fullStr | Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer |
| title_full_unstemmed | Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer |
| title_short | Comparison of BRCA1 Gene Expression and CA15-3 Tumor Marker Level in Different Stages of Breast Cancer |
| title_sort | comparison of brca1 gene expression and ca15 3 tumor marker level in different stages of breast cancer |
| url | http://dx.doi.org/10.1155/2024/3461694 |
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