Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia
Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional s...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2017/8965729 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565241571966976 |
|---|---|
| author | Muluken Birhanu Yaregal Asres Wondimagegn Adissu Tilahun Yemane Endalew Zemene Lealem Gedefaw |
| author_facet | Muluken Birhanu Yaregal Asres Wondimagegn Adissu Tilahun Yemane Endalew Zemene Lealem Gedefaw |
| author_sort | Muluken Birhanu |
| collection | DOAJ |
| description | Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations. Data were analyzed using SPSS version 20. The overall prevalence of anemia was 40.3%, most of which were mildly anemic. Leukocytosis was found in 15.4% of study participants. More than a fourth (27%) of the children had severe malaria. Hemozoin-containing monocytes and neutrophils were found in 80.1% and 58.9% of the study participants, respectively. Under-five years of age (AOR = 3.01, 95% CI: 1.83–7.39, P<0.001), leukocytosis (AOR = 3.20, 95% CI: 1.65–6.24, P=0.001), mean hemozoin-containing monocytes >5% (AOR = 6.26, 95% CI: 2.14–14.29, P<0.001), mean hemozoin-containing neutrophils >5% (AOR = 7.93, 95% CI: 3.09–16.86, P<0.001), and high density parasitemia (AOR = 1.90, 95% CI: 1.13–3.18, P=0.015) were associated with severe malaria. Hemozoin-containing leukocytes, leukocytosis, and other identified associated factors should be considered for proper management of children with severe malaria. |
| format | Article |
| id | doaj-art-760d94deff6249fcae14d68b06d84084 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-760d94deff6249fcae14d68b06d840842025-02-03T01:08:56ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982017-01-01201710.1155/2017/89657298965729Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest EthiopiaMuluken Birhanu0Yaregal Asres1Wondimagegn Adissu2Tilahun Yemane3Endalew Zemene4Lealem Gedefaw5Department of Medical Laboratory Science, Assosa University, Assosa, EthiopiaDepartment of Medical Laboratory Science and Pathology, College of Health Sciences, Jimma University, Jimma, EthiopiaDepartment of Medical Laboratory Science and Pathology, College of Health Sciences, Jimma University, Jimma, EthiopiaDepartment of Medical Laboratory Science and Pathology, College of Health Sciences, Jimma University, Jimma, EthiopiaDepartment of Medical Laboratory Science and Pathology, College of Health Sciences, Jimma University, Jimma, EthiopiaDepartment of Medical Laboratory Science and Pathology, College of Health Sciences, Jimma University, Jimma, EthiopiaHematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations. Data were analyzed using SPSS version 20. The overall prevalence of anemia was 40.3%, most of which were mildly anemic. Leukocytosis was found in 15.4% of study participants. More than a fourth (27%) of the children had severe malaria. Hemozoin-containing monocytes and neutrophils were found in 80.1% and 58.9% of the study participants, respectively. Under-five years of age (AOR = 3.01, 95% CI: 1.83–7.39, P<0.001), leukocytosis (AOR = 3.20, 95% CI: 1.65–6.24, P=0.001), mean hemozoin-containing monocytes >5% (AOR = 6.26, 95% CI: 2.14–14.29, P<0.001), mean hemozoin-containing neutrophils >5% (AOR = 7.93, 95% CI: 3.09–16.86, P<0.001), and high density parasitemia (AOR = 1.90, 95% CI: 1.13–3.18, P=0.015) were associated with severe malaria. Hemozoin-containing leukocytes, leukocytosis, and other identified associated factors should be considered for proper management of children with severe malaria.http://dx.doi.org/10.1155/2017/8965729 |
| spellingShingle | Muluken Birhanu Yaregal Asres Wondimagegn Adissu Tilahun Yemane Endalew Zemene Lealem Gedefaw Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia Interdisciplinary Perspectives on Infectious Diseases |
| title | Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia |
| title_full | Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia |
| title_fullStr | Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia |
| title_full_unstemmed | Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia |
| title_short | Hematological Parameters and Hemozoin-Containing Leukocytes and Their Association with Disease Severity among Malaria Infected Children: A Cross-Sectional Study at Pawe General Hospital, Northwest Ethiopia |
| title_sort | hematological parameters and hemozoin containing leukocytes and their association with disease severity among malaria infected children a cross sectional study at pawe general hospital northwest ethiopia |
| url | http://dx.doi.org/10.1155/2017/8965729 |
| work_keys_str_mv | AT mulukenbirhanu hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia AT yaregalasres hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia AT wondimagegnadissu hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia AT tilahunyemane hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia AT endalewzemene hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia AT lealemgedefaw hematologicalparametersandhemozoincontainingleukocytesandtheirassociationwithdiseaseseverityamongmalariainfectedchildrenacrosssectionalstudyatpawegeneralhospitalnorthwestethiopia |