Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery
Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeabili...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/81 |
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| author | Adila Nazli Milo Malanga Tamás Sohajda Szabolcs Béni |
| author_facet | Adila Nazli Milo Malanga Tamás Sohajda Szabolcs Béni |
| author_sort | Adila Nazli |
| collection | DOAJ |
| description | Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cationic moieties that are commonly employed in the design of cyclodextrins with enhanced complexation ability. Subsequently, a wide range of cationic cyclodextrin-based drug delivery systems were analyzed with emphasis on chemistry, drug release profiles, and therapeutic outcomes. The evaluation of the delivery platforms was also based on the four major types of drugs, such as anticancer, anti-inflammatory, antibacterial, and antidiabetic agents. The delivery systems for nucleic acids were also summarized while focusing on their condensation ability, transfection efficiency, and biocompatibility in comparison to commercially available vectors such as PEI 25 kDa and lipofectamine 2000. Furthermore, we highlighted the potential of cationic cyclodextrins in constructing multimodal delivery systems for the simultaneous encapsulation of both drugs and nucleic acids. Finally, the challenges and limitations associated with cationic cyclodextrin setups were discussed. |
| format | Article |
| id | doaj-art-760d0271611b4f5583c938a86eb90dcf |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-760d0271611b4f5583c938a86eb90dcf2025-01-24T13:45:52ZengMDPI AGPharmaceutics1999-49232025-01-011718110.3390/pharmaceutics17010081Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid DeliveryAdila Nazli0Milo Malanga1Tamás Sohajda2Szabolcs Béni3Department of Pharmacognosy, Semmelweis University, 1085 Budapest, HungaryCarboHyde Zrt., Berlini u. 47-49, 1045 Budapest, HungaryCarboHyde Zrt., Berlini u. 47-49, 1045 Budapest, HungaryIntegrative Health and Environmental Analysis Research Laboratory, Department of Analytical Chemistry, Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, HungaryCyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cationic moieties that are commonly employed in the design of cyclodextrins with enhanced complexation ability. Subsequently, a wide range of cationic cyclodextrin-based drug delivery systems were analyzed with emphasis on chemistry, drug release profiles, and therapeutic outcomes. The evaluation of the delivery platforms was also based on the four major types of drugs, such as anticancer, anti-inflammatory, antibacterial, and antidiabetic agents. The delivery systems for nucleic acids were also summarized while focusing on their condensation ability, transfection efficiency, and biocompatibility in comparison to commercially available vectors such as PEI 25 kDa and lipofectamine 2000. Furthermore, we highlighted the potential of cationic cyclodextrins in constructing multimodal delivery systems for the simultaneous encapsulation of both drugs and nucleic acids. Finally, the challenges and limitations associated with cationic cyclodextrin setups were discussed.https://www.mdpi.com/1999-4923/17/1/81targeted drug releasetransfection efficiencyinclusion complexplasmid DNAmicroRNAsmall interfering RNA |
| spellingShingle | Adila Nazli Milo Malanga Tamás Sohajda Szabolcs Béni Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery Pharmaceutics targeted drug release transfection efficiency inclusion complex plasmid DNA microRNA small interfering RNA |
| title | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery |
| title_full | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery |
| title_fullStr | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery |
| title_full_unstemmed | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery |
| title_short | Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery |
| title_sort | cationic cyclodextrin based carriers for drug and nucleic acid delivery |
| topic | targeted drug release transfection efficiency inclusion complex plasmid DNA microRNA small interfering RNA |
| url | https://www.mdpi.com/1999-4923/17/1/81 |
| work_keys_str_mv | AT adilanazli cationiccyclodextrinbasedcarriersfordrugandnucleicaciddelivery AT milomalanga cationiccyclodextrinbasedcarriersfordrugandnucleicaciddelivery AT tamassohajda cationiccyclodextrinbasedcarriersfordrugandnucleicaciddelivery AT szabolcsbeni cationiccyclodextrinbasedcarriersfordrugandnucleicaciddelivery |