Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study
Introduction Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogene...
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2022-06-01
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| author | Johan Burisch Lene Terslev Mikkel Østergaard Annette Bøjer Jensen Frank Krieger Jensen Flemming Bendtsen Charlotte Wiell Mohamed Attauabi Klaus Theede Viktoria Fana Hartwig Roman Siebner Henrik S Thomsen Jakob M Møller Simon Francis Thomsen Gorm Roager Madsen Anne Vibeke Wewer Rune Wilkens Johan Ilvemark Nora Vladimirova Sanja Bay Hansen Yousef Jesper Wirenfeldt Nielsen Helene Andrea Sinclair Ingels Trine Boysen Jacob T Bjerrum Christian Jakobsen Maria Dorn-Rasmussen Sabine Jansson Yiqiu Yao Ewa Anna Burian Frederik Trier Møller Kristina Bertl Andreas Stavropoulos Jakob B Seidelin |
| author_facet | Johan Burisch Lene Terslev Mikkel Østergaard Annette Bøjer Jensen Frank Krieger Jensen Flemming Bendtsen Charlotte Wiell Mohamed Attauabi Klaus Theede Viktoria Fana Hartwig Roman Siebner Henrik S Thomsen Jakob M Møller Simon Francis Thomsen Gorm Roager Madsen Anne Vibeke Wewer Rune Wilkens Johan Ilvemark Nora Vladimirova Sanja Bay Hansen Yousef Jesper Wirenfeldt Nielsen Helene Andrea Sinclair Ingels Trine Boysen Jacob T Bjerrum Christian Jakobsen Maria Dorn-Rasmussen Sabine Jansson Yiqiu Yao Ewa Anna Burian Frederik Trier Møller Kristina Bertl Andreas Stavropoulos Jakob B Seidelin |
| author_sort | Johan Burisch |
| collection | DOAJ |
| description | Introduction Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.Methods and analysis IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences. |
| format | Article |
| id | doaj-art-76004068575948ef84d63527915e8b99 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-76004068575948ef84d63527915e8b992025-01-24T07:20:13ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-055779Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort StudyJohan Burisch0Lene Terslev1Mikkel Østergaard2Annette Bøjer Jensen3Frank Krieger Jensen4Flemming Bendtsen5Charlotte Wiell6Mohamed Attauabi7Klaus Theede8Viktoria Fana9Hartwig Roman Siebner10Henrik S Thomsen11Jakob M Møller12Simon Francis Thomsen13Gorm Roager Madsen14Anne Vibeke Wewer15Rune Wilkens16Johan Ilvemark17Nora Vladimirova18Sanja Bay Hansen19Yousef Jesper Wirenfeldt Nielsen20Helene Andrea Sinclair Ingels21Trine Boysen22Jacob T Bjerrum23Christian Jakobsen24Maria Dorn-Rasmussen25Sabine Jansson26Yiqiu Yao27Ewa Anna Burian28Frederik Trier Møller29Kristina Bertl30Andreas Stavropoulos31Jakob B Seidelin32Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkCentre for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark2 Department of Clinical Medicine, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark3 Department of Radiology, Hvidovre Hospital, Hvidovre, Denmark3 Department of Radiology, Hvidovre Hospital, Hvidovre, Denmark3 Gastrounit Medical Division, Hvidovre Hospital, Hvidovre, Denmark13 Department of Rheumatology, Gentofte University Hospital, Hellerup, DenmarkDepartment of Gastroenterology and Hepatology, Copenhagen University Hospital—Herlev and Gentofte, Herlev Hospital, Copenhagen, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkRigshospitalet-Glostrup, Center for Rheumatology and Spine Diseases, Copenhagen, DenmarkDepartment of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, DenmarkDepartment of Radiology, Herlev Hospital, Herlev, DenmarkDepartment of Radiology, Herlev Hospital, Herlev, Denmark1 Department of Dermatology, Bispebjerg Hospital, Copenhagen, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, DenmarkCopenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, DenmarkDepartment of Radiology, Centre for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, DenmarkDepartment of Radiology, Herlev Hospital, Herlev, DenmarkDepartment of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Kobenhavn, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkCopenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Hvidovre Hospital, Hvidovre, DenmarkThe Paediatric Department, Hvidovre Hospital, Hvidovre, DenmarkDepartment of Dermatology, Bispebjerg Hospital, Kobenhavn, DenmarkDepartment of Dermatology, Bispebjerg Hospital, Kobenhavn, DenmarkDepartment of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, DenmarkDepartment of Periodontology, Malmö Universitet, Malmo, SwedenMalmo Universitet, Malmo, SwedenDepartment of Gastroenterology and Hepatology, Herlev Hospital, Herlev, DenmarkIntroduction Inflammatory bowel diseases (IBD), encompassing Crohn’s disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.Methods and analysis IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.Ethics and dissemination This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.https://bmjopen.bmj.com/content/12/6/e055779.full |
| spellingShingle | Johan Burisch Lene Terslev Mikkel Østergaard Annette Bøjer Jensen Frank Krieger Jensen Flemming Bendtsen Charlotte Wiell Mohamed Attauabi Klaus Theede Viktoria Fana Hartwig Roman Siebner Henrik S Thomsen Jakob M Møller Simon Francis Thomsen Gorm Roager Madsen Anne Vibeke Wewer Rune Wilkens Johan Ilvemark Nora Vladimirova Sanja Bay Hansen Yousef Jesper Wirenfeldt Nielsen Helene Andrea Sinclair Ingels Trine Boysen Jacob T Bjerrum Christian Jakobsen Maria Dorn-Rasmussen Sabine Jansson Yiqiu Yao Ewa Anna Burian Frederik Trier Møller Kristina Bertl Andreas Stavropoulos Jakob B Seidelin Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study BMJ Open |
| title | Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study |
| title_full | Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study |
| title_fullStr | Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study |
| title_full_unstemmed | Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study |
| title_short | Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study): the protocol for a Copenhagen IBD Inception Cohort Study |
| title_sort | influence of genetics immunity and the microbiome on the prognosis of inflammatory bowel disease ibd prognosis study the protocol for a copenhagen ibd inception cohort study |
| url | https://bmjopen.bmj.com/content/12/6/e055779.full |
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