Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group
Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n=28), microalbuminuria (n=28), and macroalbuminuria (n=28) with their first degree relatives (n=28) and health...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/167154 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549861452414976 |
|---|---|
| author | Parisa Behzadi Firouzeh Torabi Massoud Amini Ashraf Aminorroaya |
| author_facet | Parisa Behzadi Firouzeh Torabi Massoud Amini Ashraf Aminorroaya |
| author_sort | Parisa Behzadi |
| collection | DOAJ |
| description | Oxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n=28), microalbuminuria (n=28), and macroalbuminuria (n=28) with their first degree relatives (n=28) and healthy control people (n=31). They were selected by consecutive patient selection method. The ox-LDL level was assayed using ELISA. We measured blood pressure, lipid profile, fasting plasma glucose (FPG), and HbA1c in all groups. There was no significant difference in ox-LDL concentrations among normoalbuminuric, microalbuminuric, and macroalbuminuric diabetic groups. In diabetic patients with micro- and macroalbuminuria, ox-LDL concentration was higher than their first degree relatives (P=0.04 and P=0.03) and control group (P=0.001 and P=0.03, resp.). In normoalbuminuric diabetic persons, ox-LDL concentration was just higher than that of healthy people (P=0.02). There was no statistically significant difference in ox-LDL levels between normoalbuminuric diabetic patients and their first degree relatives. In conclusion, the presence and progression of albuminuria in diabetic patients are not related to ox-LDL concentration and genetic predisposition influences the plasma OX-LDL level. Larger sample size is needed to confirm this conclusion in future studies. |
| format | Article |
| id | doaj-art-75fc1e326b4d43f4872b9acc1903603e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-75fc1e326b4d43f4872b9acc1903603e2025-02-03T06:08:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/167154167154Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control GroupParisa Behzadi0Firouzeh Torabi1Massoud Amini2Ashraf Aminorroaya3Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, IranInternal Medicine and Endocrinology, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Research Complex, Khorram Street, 8187698191 Isfahan, IranInternal Medicine and Endocrinology, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Sedigheh Tahereh Research Complex, Khorram Street, 8187698191 Isfahan, IranOxidized low density lipoprotein (ox-LDL) is a product of oxidative stress. In this cross-sectional study, we compared the ox-LDL concentrations in diabetic patients with normoalbuminuria (n=28), microalbuminuria (n=28), and macroalbuminuria (n=28) with their first degree relatives (n=28) and healthy control people (n=31). They were selected by consecutive patient selection method. The ox-LDL level was assayed using ELISA. We measured blood pressure, lipid profile, fasting plasma glucose (FPG), and HbA1c in all groups. There was no significant difference in ox-LDL concentrations among normoalbuminuric, microalbuminuric, and macroalbuminuric diabetic groups. In diabetic patients with micro- and macroalbuminuria, ox-LDL concentration was higher than their first degree relatives (P=0.04 and P=0.03) and control group (P=0.001 and P=0.03, resp.). In normoalbuminuric diabetic persons, ox-LDL concentration was just higher than that of healthy people (P=0.02). There was no statistically significant difference in ox-LDL levels between normoalbuminuric diabetic patients and their first degree relatives. In conclusion, the presence and progression of albuminuria in diabetic patients are not related to ox-LDL concentration and genetic predisposition influences the plasma OX-LDL level. Larger sample size is needed to confirm this conclusion in future studies.http://dx.doi.org/10.1155/2012/167154 |
| spellingShingle | Parisa Behzadi Firouzeh Torabi Massoud Amini Ashraf Aminorroaya Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group International Journal of Endocrinology |
| title | Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group |
| title_full | Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group |
| title_fullStr | Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group |
| title_full_unstemmed | Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group |
| title_short | Comparison of ox-LDL Levels in Diabetic Patients with Normo-, Micro-, and Macroalbuminuria with Their First Degree Relatives and the Healthy Control Group |
| title_sort | comparison of ox ldl levels in diabetic patients with normo micro and macroalbuminuria with their first degree relatives and the healthy control group |
| url | http://dx.doi.org/10.1155/2012/167154 |
| work_keys_str_mv | AT parisabehzadi comparisonofoxldllevelsindiabeticpatientswithnormomicroandmacroalbuminuriawiththeirfirstdegreerelativesandthehealthycontrolgroup AT firouzehtorabi comparisonofoxldllevelsindiabeticpatientswithnormomicroandmacroalbuminuriawiththeirfirstdegreerelativesandthehealthycontrolgroup AT massoudamini comparisonofoxldllevelsindiabeticpatientswithnormomicroandmacroalbuminuriawiththeirfirstdegreerelativesandthehealthycontrolgroup AT ashrafaminorroaya comparisonofoxldllevelsindiabeticpatientswithnormomicroandmacroalbuminuriawiththeirfirstdegreerelativesandthehealthycontrolgroup |