Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study
Binge Drinking (BD) is characterized by consuming large amounts of alcohol on one occasion, posing risks to brain function. Nonetheless, it remains the most prevalent consumption pattern among students. Cross-sectional studies have explored the relationship between BD and anomalies in resting-state...
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Elsevier
2025-06-01
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| Series: | Addictive Behaviors Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352853225000033 |
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| author | Samuel Suárez-Suárez Fernando Cadaveira Alfonso Barrós-Loscertales José Manuel Pérez-García Socorro Rodríguez Holguín Javier Blanco-Ramos Sonia Doallo |
| author_facet | Samuel Suárez-Suárez Fernando Cadaveira Alfonso Barrós-Loscertales José Manuel Pérez-García Socorro Rodríguez Holguín Javier Blanco-Ramos Sonia Doallo |
| author_sort | Samuel Suárez-Suárez |
| collection | DOAJ |
| description | Binge Drinking (BD) is characterized by consuming large amounts of alcohol on one occasion, posing risks to brain function. Nonetheless, it remains the most prevalent consumption pattern among students. Cross-sectional studies have explored the relationship between BD and anomalies in resting-state functional connectivity (RS-FC), but the medium/long-term consequences of BD on RS-FC during developmental periods remain relatively unexplored. In this two-year follow-up study, the impact of sustained BD on RS-FC was investigated in 44 college students (16 binge-drinkers) via two fMRI sessions at ages 18–19 and 20–21. Using a seed-to-voxel approach, RS-FC differences were examined in nodes of the main brain functional networks vulnerable to alcohol misuse, according to previous studies. Group differences in RS-FC were observed in four of the explored brain regions. Binge drinkers, compared to the control group, exhibited, at the second assessment, decreased connectivity between the right SFG (executive control network) and right precentral gyrus, the ACC (salience network) and right postcentral gyrus, and the left amygdala (emotional network) and medial frontal gyrus/dorsal ACC. Conversely, binge drinkers showed increased connectivity between the right Nacc (reward network) and four clusters comprising bilateral middle frontal gyrus (MFG), right middle cingulate cortex, and right MFG extending to SFG. Maintaining a BD pattern during critical neurodevelopmental years impacts RS-FC, indicating mid-to-long-term alterations in functional brain organization. This study provides new insights into the neurotoxic effects of adolescent alcohol misuse, emphasizing the need for longitudinal studies addressing the lasting consequences on brain functional connectivity. |
| format | Article |
| id | doaj-art-75dd3ef1e60c4c8d8e4c4b833713fd74 |
| institution | Kabale University |
| issn | 2352-8532 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addictive Behaviors Reports |
| spelling | doaj-art-75dd3ef1e60c4c8d8e4c4b833713fd742025-01-18T05:04:50ZengElsevierAddictive Behaviors Reports2352-85322025-06-0121100585Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up studySamuel Suárez-Suárez0Fernando Cadaveira1Alfonso Barrós-Loscertales2José Manuel Pérez-García3Socorro Rodríguez Holguín4Javier Blanco-Ramos5Sonia Doallo6Department of Health Sciences, University of Burgos 09001 Burgos, SpainDepartamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Psicoloxía (IPsiUS), Universidade de Santiago de Compostela, SpainDepartamento de Psicología Básica, ClínicaSpain y Psicobiología, Universitat Jaume I, Castelló de la Plana, SpainDepartment of Educational Psychology and Psychobiology, Faculty of Education, Universidad Internacional de La Rioja, Logroño, SpainDepartamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Psicoloxía (IPsiUS), Universidade de Santiago de Compostela, SpainDepartment of Educational Psychology and Psychobiology, Faculty of Education, Universidad Internacional de La Rioja, Logroño, Spain; Fundación Pública Andaluza para la Investigación Biosanitaria en Andalucía Oriental, FIBAO, SpainDepartamento de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Psicoloxía (IPsiUS), Universidade de Santiago de Compostela, Spain; Corresponding author at: Dpto. de Psicoloxía Clínica e Psicobioloxía, Facultade de Psicoloxía, Universidade de Santiago de Compostela.Binge Drinking (BD) is characterized by consuming large amounts of alcohol on one occasion, posing risks to brain function. Nonetheless, it remains the most prevalent consumption pattern among students. Cross-sectional studies have explored the relationship between BD and anomalies in resting-state functional connectivity (RS-FC), but the medium/long-term consequences of BD on RS-FC during developmental periods remain relatively unexplored. In this two-year follow-up study, the impact of sustained BD on RS-FC was investigated in 44 college students (16 binge-drinkers) via two fMRI sessions at ages 18–19 and 20–21. Using a seed-to-voxel approach, RS-FC differences were examined in nodes of the main brain functional networks vulnerable to alcohol misuse, according to previous studies. Group differences in RS-FC were observed in four of the explored brain regions. Binge drinkers, compared to the control group, exhibited, at the second assessment, decreased connectivity between the right SFG (executive control network) and right precentral gyrus, the ACC (salience network) and right postcentral gyrus, and the left amygdala (emotional network) and medial frontal gyrus/dorsal ACC. Conversely, binge drinkers showed increased connectivity between the right Nacc (reward network) and four clusters comprising bilateral middle frontal gyrus (MFG), right middle cingulate cortex, and right MFG extending to SFG. Maintaining a BD pattern during critical neurodevelopmental years impacts RS-FC, indicating mid-to-long-term alterations in functional brain organization. This study provides new insights into the neurotoxic effects of adolescent alcohol misuse, emphasizing the need for longitudinal studies addressing the lasting consequences on brain functional connectivity.http://www.sciencedirect.com/science/article/pii/S2352853225000033Binge drinkingResting-stateFunctional magnetic resonance imagingFunctional connectivityAdolescence |
| spellingShingle | Samuel Suárez-Suárez Fernando Cadaveira Alfonso Barrós-Loscertales José Manuel Pérez-García Socorro Rodríguez Holguín Javier Blanco-Ramos Sonia Doallo Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study Addictive Behaviors Reports Binge drinking Resting-state Functional magnetic resonance imaging Functional connectivity Adolescence |
| title | Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study |
| title_full | Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study |
| title_fullStr | Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study |
| title_full_unstemmed | Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study |
| title_short | Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study |
| title_sort | influence of binge drinking on the resting state functional connectivity of university students a follow up study |
| topic | Binge drinking Resting-state Functional magnetic resonance imaging Functional connectivity Adolescence |
| url | http://www.sciencedirect.com/science/article/pii/S2352853225000033 |
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