Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity
Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/560938 |
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| author | Silvia Barja-Fernández Cintia Folgueira Cecilia Castelao Rosaura Leis Felipe F. Casanueva Luisa M. Seoane |
| author_facet | Silvia Barja-Fernández Cintia Folgueira Cecilia Castelao Rosaura Leis Felipe F. Casanueva Luisa M. Seoane |
| author_sort | Silvia Barja-Fernández |
| collection | DOAJ |
| description | Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in the pattern of gastrointestinal hormones production appear to be responsible for the beneficial effect. The gastrointestinal tract has emerged in the last time as an endocrine organ in charge of response to the different stimulus related to nutritional status by the modulation of more than 30 signals acting at central level to modulate food intake and body weight. The production of some of these gastric derived signals has been proved to be altered in obesity (ghrelin, CCK, and GLP-1). In fact, bariatric surgery modifies the production of both gastrointestinal and adipose tissue peripheral signals beyond the gut microbiota composition. Through this paper the main peripheral signals altered in obesity will be reviewed together with their modifications after bariatric surgery. |
| format | Article |
| id | doaj-art-75ca2402ae334dfa8f4ed5bb295ddb37 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-75ca2402ae334dfa8f4ed5bb295ddb372025-02-03T06:08:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/560938560938Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in ObesitySilvia Barja-Fernández0Cintia Folgueira1Cecilia Castelao2Rosaura Leis3Felipe F. Casanueva4Luisa M. Seoane5Grupo Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, SpainGrupo Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, SpainGrupo Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, SpainDepartamento de Pediatría, Universidad de Santiago de Compostela (USC), Instituto de Investigación Sanitaria de Santiago de Compostela, Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, SpainGrupo Fisiopatología Endocrina, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago (CHUS/SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, SpainObesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in the pattern of gastrointestinal hormones production appear to be responsible for the beneficial effect. The gastrointestinal tract has emerged in the last time as an endocrine organ in charge of response to the different stimulus related to nutritional status by the modulation of more than 30 signals acting at central level to modulate food intake and body weight. The production of some of these gastric derived signals has been proved to be altered in obesity (ghrelin, CCK, and GLP-1). In fact, bariatric surgery modifies the production of both gastrointestinal and adipose tissue peripheral signals beyond the gut microbiota composition. Through this paper the main peripheral signals altered in obesity will be reviewed together with their modifications after bariatric surgery.http://dx.doi.org/10.1155/2015/560938 |
| spellingShingle | Silvia Barja-Fernández Cintia Folgueira Cecilia Castelao Rosaura Leis Felipe F. Casanueva Luisa M. Seoane Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity Gastroenterology Research and Practice |
| title | Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity |
| title_full | Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity |
| title_fullStr | Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity |
| title_full_unstemmed | Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity |
| title_short | Peripheral Signals Mediate the Beneficial Effects of Gastric Surgery in Obesity |
| title_sort | peripheral signals mediate the beneficial effects of gastric surgery in obesity |
| url | http://dx.doi.org/10.1155/2015/560938 |
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