Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment
In the complex tumor microenvironment, chemical and mechanical signals from tumor cells, stromal cells, and the surrounding extracellular matrix influence all aspects of disease progression and response to treatment. Modeling the physical properties of the tumor microenvironment has been a significa...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2017/5204163 |
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| _version_ | 1832564204546031616 |
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| author | Marshall Hunter Joyce Shane Allen Laura Suggs Amy Brock |
| author_facet | Marshall Hunter Joyce Shane Allen Laura Suggs Amy Brock |
| author_sort | Marshall Hunter Joyce |
| collection | DOAJ |
| description | In the complex tumor microenvironment, chemical and mechanical signals from tumor cells, stromal cells, and the surrounding extracellular matrix influence all aspects of disease progression and response to treatment. Modeling the physical properties of the tumor microenvironment has been a significant effort in the biomaterials field. One challenge has been the difficulty in altering the mechanical properties of the extracellular matrix without simultaneously impacting other factors that influence cell behavior. The development of novel materials based on nanotechnology has enabled recent innovations in tumor cell culture models. Here, we review the various approaches by which the tumor cell microenvironment has been engineered using natural and synthetic gels. We describe new studies that rely on the unique temporal and spatial control afforded by nanomaterials to produce culture platforms that mimic dynamic changes in tumor matrix mechanics. In addition, we look at the frontier of nanomaterial-hydrogel composites to review new approaches for perturbation of mechanochemical control in the tumor microenvironment. |
| format | Article |
| id | doaj-art-75c6029ead0847119a295c2b4a95263c |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-75c6029ead0847119a295c2b4a95263c2025-02-03T01:11:38ZengWileyJournal of Nanotechnology1687-95031687-95112017-01-01201710.1155/2017/52041635204163Novel Nanomaterials Enable Biomimetic Models of the Tumor MicroenvironmentMarshall Hunter Joyce0Shane Allen1Laura Suggs2Amy Brock3Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USADepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USADepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USADepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USAIn the complex tumor microenvironment, chemical and mechanical signals from tumor cells, stromal cells, and the surrounding extracellular matrix influence all aspects of disease progression and response to treatment. Modeling the physical properties of the tumor microenvironment has been a significant effort in the biomaterials field. One challenge has been the difficulty in altering the mechanical properties of the extracellular matrix without simultaneously impacting other factors that influence cell behavior. The development of novel materials based on nanotechnology has enabled recent innovations in tumor cell culture models. Here, we review the various approaches by which the tumor cell microenvironment has been engineered using natural and synthetic gels. We describe new studies that rely on the unique temporal and spatial control afforded by nanomaterials to produce culture platforms that mimic dynamic changes in tumor matrix mechanics. In addition, we look at the frontier of nanomaterial-hydrogel composites to review new approaches for perturbation of mechanochemical control in the tumor microenvironment.http://dx.doi.org/10.1155/2017/5204163 |
| spellingShingle | Marshall Hunter Joyce Shane Allen Laura Suggs Amy Brock Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment Journal of Nanotechnology |
| title | Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment |
| title_full | Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment |
| title_fullStr | Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment |
| title_full_unstemmed | Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment |
| title_short | Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment |
| title_sort | novel nanomaterials enable biomimetic models of the tumor microenvironment |
| url | http://dx.doi.org/10.1155/2017/5204163 |
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