Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon
<b>Background:</b> Urinary tract infections (UTIs) are a substantial global health concern, exacerbated by the widespread use of antibiotics and leading to the development of multidrug-resistant strains. The aim of this study was to analyze the temporal patterns of <i>Escherichia c...
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2024-12-01
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| author | Yann Mouanga-Ndzime Cyrille Bisseye Neil-Michel Longo-Pendy Michelle Bignoumba Anicet-Clotaire Dikoumba Richard Onanga |
| author_facet | Yann Mouanga-Ndzime Cyrille Bisseye Neil-Michel Longo-Pendy Michelle Bignoumba Anicet-Clotaire Dikoumba Richard Onanga |
| author_sort | Yann Mouanga-Ndzime |
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| description | <b>Background:</b> Urinary tract infections (UTIs) are a substantial global health concern, exacerbated by the widespread use of antibiotics and leading to the development of multidrug-resistant strains. The aim of this study was to analyze the temporal patterns of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> UTIs and antibiotic resistance, taking into account various sociodemographic, clinical, and climatic factors within the study population. <b>Methods:</b> A total of 3026 urine samples from patients of all ages were analyzed over a period of five years by standard microbiological methods. Climatic data for the study area were also collected. Univariate and multivariate logistic regression analyses were performed to measure the impact of sociodemographic, clinical and climatic parameters on the occurrence of UTIs. <b>Results:</b> The study showed a 31.4% prevalence of UTIs among the population. Notably, there was a significant increase in pyelonephritis between 2019 and 2023 (<i>p</i> < 0.01). Furthermore, a significant association was found between cystitis and the long dry season, as well as the short rainy season. Furthermore, <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> exhibited resistance to beta-lactams, quinolones, and co-trimoxazole. The resistance of <i>Escherichia coli</i> isolated from cystitis to nitrofurantoin showed a significant increase over the years (<i>p</i> < 0.04). Principal component analysis (PCA) suggested that humidity may play a role in the emergence of multidrug-resistant strains of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>. <b>Conclusions:</b> UTIs show variability according to various sociodemographic, clinical, and climatic factors, with a higher risk of complications seen in individuals aged ≤ 17 years. It is important to note that cases of pyelonephritis have been increasing over time, with a noticeable seasonal variation. This study suggests that humidity may play a role in promoting antibiotic multidrug resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>. |
| format | Article |
| id | doaj-art-75c1e3020e9746a2a3ff7323d3cbad12 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-75c1e3020e9746a2a3ff7323d3cbad122025-01-24T13:18:32ZengMDPI AGAntibiotics2079-63822024-12-011411410.3390/antibiotics14010014Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern GabonYann Mouanga-Ndzime0Cyrille Bisseye1Neil-Michel Longo-Pendy2Michelle Bignoumba3Anicet-Clotaire Dikoumba4Richard Onanga5Medical Research and Analysis Unit, Bacteriology Laboratory, Interdisciplinary Centre for Medical Research of Franceville, Franceville P.O. Box 769, GabonDepartment of Biology, Faculty of Sciences, University of Science and Technology of Masuku, Franceville P.O. Box 943, GabonResearch Unit for the Ecology of Health, Interdisciplinary Centre for Medical Research of Franceville, Franceville P.O. Box 769, GabonMedical Research and Analysis Unit, Bacteriology Laboratory, Interdisciplinary Centre for Medical Research of Franceville, Franceville P.O. Box 769, GabonMedical Research and Analysis Unit, Bacteriology Laboratory, Interdisciplinary Centre for Medical Research of Franceville, Franceville P.O. Box 769, GabonMedical Research and Analysis Unit, Bacteriology Laboratory, Interdisciplinary Centre for Medical Research of Franceville, Franceville P.O. Box 769, Gabon<b>Background:</b> Urinary tract infections (UTIs) are a substantial global health concern, exacerbated by the widespread use of antibiotics and leading to the development of multidrug-resistant strains. The aim of this study was to analyze the temporal patterns of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> UTIs and antibiotic resistance, taking into account various sociodemographic, clinical, and climatic factors within the study population. <b>Methods:</b> A total of 3026 urine samples from patients of all ages were analyzed over a period of five years by standard microbiological methods. Climatic data for the study area were also collected. Univariate and multivariate logistic regression analyses were performed to measure the impact of sociodemographic, clinical and climatic parameters on the occurrence of UTIs. <b>Results:</b> The study showed a 31.4% prevalence of UTIs among the population. Notably, there was a significant increase in pyelonephritis between 2019 and 2023 (<i>p</i> < 0.01). Furthermore, a significant association was found between cystitis and the long dry season, as well as the short rainy season. Furthermore, <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> exhibited resistance to beta-lactams, quinolones, and co-trimoxazole. The resistance of <i>Escherichia coli</i> isolated from cystitis to nitrofurantoin showed a significant increase over the years (<i>p</i> < 0.04). Principal component analysis (PCA) suggested that humidity may play a role in the emergence of multidrug-resistant strains of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>. <b>Conclusions:</b> UTIs show variability according to various sociodemographic, clinical, and climatic factors, with a higher risk of complications seen in individuals aged ≤ 17 years. It is important to note that cases of pyelonephritis have been increasing over time, with a noticeable seasonal variation. This study suggests that humidity may play a role in promoting antibiotic multidrug resistance in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>.https://www.mdpi.com/2079-6382/14/1/14UTIs<i>Escherichia coli</i><i>Klebsiella pneumoniae</i>sociodemographic and climatic factorsantibiotic resistance |
| spellingShingle | Yann Mouanga-Ndzime Cyrille Bisseye Neil-Michel Longo-Pendy Michelle Bignoumba Anicet-Clotaire Dikoumba Richard Onanga Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon Antibiotics UTIs <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> sociodemographic and climatic factors antibiotic resistance |
| title | Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon |
| title_full | Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon |
| title_fullStr | Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon |
| title_full_unstemmed | Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon |
| title_short | Trends in <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Urinary Tract Infections and Antibiotic Resistance over a 5-Year Period in Southeastern Gabon |
| title_sort | trends in i escherichia coli i and i klebsiella pneumoniae i urinary tract infections and antibiotic resistance over a 5 year period in southeastern gabon |
| topic | UTIs <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> sociodemographic and climatic factors antibiotic resistance |
| url | https://www.mdpi.com/2079-6382/14/1/14 |
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