Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer
Cancer is the most dreaded disease in human and also major health problem worldwide. Despite its high occurrence, the exact molecular mechanisms of the development and progression are not fully understood. The existing cancer therapy based on allopathic medicine is expensive, exhibits side effects;...
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BioMed Central
2014-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-12-156.pdf |
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| author | Perumal Elumalai Jagadeesan Arunakaran |
| author_facet | Perumal Elumalai Jagadeesan Arunakaran |
| author_sort | Perumal Elumalai |
| collection | DOAJ |
| description | Cancer is the most dreaded disease in human and also major health problem worldwide. Despite its high occurrence, the exact molecular mechanisms of the development and progression are not fully understood. The existing cancer therapy based on allopathic medicine is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, a non-toxic and effective mode of treatment is needed to control cancer development and progression. Some medicinal plants offer a safe, effective and affordable remedy to control the cancer progression. Nimbolide, a limnoid derived from the neem (Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various human diseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. The previous studies carried out over the decades have shown that nimbolide inhibits cell proliferation and metastasis of cancer cells. This review highlights the current knowledge on the molecular targets that contribute to the observed anticancer activity of nimbolide related to induction of apoptosis and cell cycle arrest; and inhibition of signaling pathways related to cancer progression. |
| format | Article |
| id | doaj-art-75bd064df88f4164bf47f7f765462cc7 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-75bd064df88f4164bf47f7f765462cc72025-02-02T02:26:05ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-12-0112415616410.5808/GI.2014.12.4.156102Review on Molecular and Chemopreventive Potential of Nimbolide in CancerPerumal Elumalai0Jagadeesan Arunakaran1Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India.Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India.Cancer is the most dreaded disease in human and also major health problem worldwide. Despite its high occurrence, the exact molecular mechanisms of the development and progression are not fully understood. The existing cancer therapy based on allopathic medicine is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, a non-toxic and effective mode of treatment is needed to control cancer development and progression. Some medicinal plants offer a safe, effective and affordable remedy to control the cancer progression. Nimbolide, a limnoid derived from the neem (Azadirachta indica) leaves and flowers of neem, is widely used in traditional medical practices for treating various human diseases. Nimbolide exhibits several pharmacological effects among which its anticancer activity is the most promising. The previous studies carried out over the decades have shown that nimbolide inhibits cell proliferation and metastasis of cancer cells. This review highlights the current knowledge on the molecular targets that contribute to the observed anticancer activity of nimbolide related to induction of apoptosis and cell cycle arrest; and inhibition of signaling pathways related to cancer progression.http://genominfo.org/upload/pdf/gni-12-156.pdfapoptosiscell proliferationchemopreventionneoplasm metastasisnimbolide |
| spellingShingle | Perumal Elumalai Jagadeesan Arunakaran Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer Genomics & Informatics apoptosis cell proliferation chemoprevention neoplasm metastasis nimbolide |
| title | Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer |
| title_full | Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer |
| title_fullStr | Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer |
| title_full_unstemmed | Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer |
| title_short | Review on Molecular and Chemopreventive Potential of Nimbolide in Cancer |
| title_sort | review on molecular and chemopreventive potential of nimbolide in cancer |
| topic | apoptosis cell proliferation chemoprevention neoplasm metastasis nimbolide |
| url | http://genominfo.org/upload/pdf/gni-12-156.pdf |
| work_keys_str_mv | AT perumalelumalai reviewonmolecularandchemopreventivepotentialofnimbolideincancer AT jagadeesanarunakaran reviewonmolecularandchemopreventivepotentialofnimbolideincancer |