Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life
Objective. Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2021/6617575 |
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| author | Zahra Hadian Ali Akbar Moghadamnia Sohrab Kazemi Atena Shirzad |
| author_facet | Zahra Hadian Ali Akbar Moghadamnia Sohrab Kazemi Atena Shirzad |
| author_sort | Zahra Hadian |
| collection | DOAJ |
| description | Objective. Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. Methods. In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann–Whitney, and chi-square tests. P<0.05 was considered as significant. Results. In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups (P<0.0001, P<0.0001, respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. Conclusion. Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life. |
| format | Article |
| id | doaj-art-75a87be7404d438aa0b2c8328a59e6c2 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-75a87be7404d438aa0b2c8328a59e6c22025-02-03T01:32:24ZengWileyInternational Journal of Dentistry1687-87281687-87362021-01-01202110.1155/2021/66175756617575Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of LifeZahra Hadian0Ali Akbar Moghadamnia1Sohrab Kazemi2Atena Shirzad3Student Research Committee, Babol University of Medical Sciences, Babol, IranPharmacology & Toxicology, Neuroscience Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranPharmaceutics Sciences, Neuroscience Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, IranOral Medicine, Oral Health Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, IranObjective. Recurrent aphthous stomatitis is one of the most common chronic inflammatory diseases in oral mucosa. Beneficial effects of omega-3 supplements on some inflammatory diseases have been proved. The aim of present study was to evaluate the effect of omega-3 supplements in recurrent aphthous stomatitis management and improve oral health-related quality of life. Methods. In this double-blind clinical trial, 40 patients with minor recurrent aphthous stomatitis were randomly divided into case and control groups. The case group received 1000 mg capsules of omega-3, while the control group received placebo capsules for 6 months. The questionnaires of the ulcer severity score and the chronic oral mucosal disease questionnaire were filled by the patients in three steps, at the baseline session, after 3 months, and after 6 months. The data were analyzed by SPSS 22 software through ANOVA, Mann–Whitney, and chi-square tests. P<0.05 was considered as significant. Results. In the omega-3 group, the ulcer severity score showed significant reduction by three-month and six-month follow-ups (P<0.0001, P<0.0001, respectively). The mean score of the chronic oral mucosal disease questionnaire significantly improved by three-month and six-month follow-ups in the omega-3-receiving group. Conclusion. Use of omega-3 oral supplements decreased the severity of aphthous ulcer and improved oral health-related quality of life.http://dx.doi.org/10.1155/2021/6617575 |
| spellingShingle | Zahra Hadian Ali Akbar Moghadamnia Sohrab Kazemi Atena Shirzad Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life International Journal of Dentistry |
| title | Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life |
| title_full | Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life |
| title_fullStr | Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life |
| title_full_unstemmed | Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life |
| title_short | Effect of Omega-3 on Recurrent Aphthous Stomatitis and Improvement Quality of Life |
| title_sort | effect of omega 3 on recurrent aphthous stomatitis and improvement quality of life |
| url | http://dx.doi.org/10.1155/2021/6617575 |
| work_keys_str_mv | AT zahrahadian effectofomega3onrecurrentaphthousstomatitisandimprovementqualityoflife AT aliakbarmoghadamnia effectofomega3onrecurrentaphthousstomatitisandimprovementqualityoflife AT sohrabkazemi effectofomega3onrecurrentaphthousstomatitisandimprovementqualityoflife AT atenashirzad effectofomega3onrecurrentaphthousstomatitisandimprovementqualityoflife |