All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants
Abstract Unlike animals, plants are unable to move and lack specialized immune cells and circulating antibodies. As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. Therefore, the development of new st...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412223 |
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| author | Aziz Ul Ikram Muhammad Saad Shoaib Khan Faisal Islam Sulaiman Ahmed Tengfang Ling Feng Feng Zongtao Sun Huan Chen Jian Chen |
| author_facet | Aziz Ul Ikram Muhammad Saad Shoaib Khan Faisal Islam Sulaiman Ahmed Tengfang Ling Feng Feng Zongtao Sun Huan Chen Jian Chen |
| author_sort | Aziz Ul Ikram |
| collection | DOAJ |
| description | Abstract Unlike animals, plants are unable to move and lack specialized immune cells and circulating antibodies. As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. Therefore, the development of new strategies to control them is essential to mitigate the increasing risk of crops lost to plant diseases. Recent developments in genetic engineering, including efficient gene manipulation and transformation methods, gene editing and synthetic biology, coupled with the understanding of microbial pathogenicity and plant immunity, both at molecular and genomic levels, have enhanced the capabilities to develop disease resistance in plants. This review comprehensively explains the fundamental mechanisms underlying the tug‐of‐war between pathogens and hosts, and provides a detailed overview of different strategies for developing disease resistance in plants. Additionally, it provides a summary of the potential genes that can be employed in resistance breeding for key crops to combat a wide range of potential pathogens and pests, including fungi, oomycetes, bacteria, viruses, nematodes, and insects. Furthermore, this review addresses the limitations associated with these strategies and their possible solutions. Finally, it discusses the future perspectives for producing plants with durable and broad‐spectrum disease resistance. |
| format | Article |
| id | doaj-art-75a279be38da43b0941bc2fbe2ca79ef |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-75a279be38da43b0941bc2fbe2ca79ef2025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202412223All Roads Lead to Rome: Pathways to Engineering Disease Resistance in PlantsAziz Ul Ikram0Muhammad Saad Shoaib Khan1Faisal Islam2Sulaiman Ahmed3Tengfang Ling4Feng Feng5Zongtao Sun6Huan Chen7Jian Chen8International Genome Center Jiangsu University Zhenjiang 212013 ChinaInternational Genome Center Jiangsu University Zhenjiang 212013 ChinaInternational Genome Center Jiangsu University Zhenjiang 212013 ChinaInternational Genome Center Jiangsu University Zhenjiang 212013 ChinaPlant Systems Engineering Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Yuseong‐gu Daejeon 34141 Republic of KoreaDepartment of Biochemistry and Molecular Biology Oklahoma State University Stillwater OK 74078 USAState Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products, Key Laboratory of Biotechnology in Plant Protection of Ministry of Agriculture and Zhejiang Province, Institute of Plant Virology Ningbo University Ningbo 315211 ChinaJoint Center for Single Cell Biology, School of Agriculture and Biology Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 ChinaInternational Genome Center Jiangsu University Zhenjiang 212013 ChinaAbstract Unlike animals, plants are unable to move and lack specialized immune cells and circulating antibodies. As a result, they are always threatened by a large number of microbial pathogens and harmful pests that can significantly reduce crop yield worldwide. Therefore, the development of new strategies to control them is essential to mitigate the increasing risk of crops lost to plant diseases. Recent developments in genetic engineering, including efficient gene manipulation and transformation methods, gene editing and synthetic biology, coupled with the understanding of microbial pathogenicity and plant immunity, both at molecular and genomic levels, have enhanced the capabilities to develop disease resistance in plants. This review comprehensively explains the fundamental mechanisms underlying the tug‐of‐war between pathogens and hosts, and provides a detailed overview of different strategies for developing disease resistance in plants. Additionally, it provides a summary of the potential genes that can be employed in resistance breeding for key crops to combat a wide range of potential pathogens and pests, including fungi, oomycetes, bacteria, viruses, nematodes, and insects. Furthermore, this review addresses the limitations associated with these strategies and their possible solutions. Finally, it discusses the future perspectives for producing plants with durable and broad‐spectrum disease resistance.https://doi.org/10.1002/advs.202412223Disease resistanceE genesGenetic engineeringNLRsPlant immunityPRRs |
| spellingShingle | Aziz Ul Ikram Muhammad Saad Shoaib Khan Faisal Islam Sulaiman Ahmed Tengfang Ling Feng Feng Zongtao Sun Huan Chen Jian Chen All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants Advanced Science Disease resistance E genes Genetic engineering NLRs Plant immunity PRRs |
| title | All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants |
| title_full | All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants |
| title_fullStr | All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants |
| title_full_unstemmed | All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants |
| title_short | All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants |
| title_sort | all roads lead to rome pathways to engineering disease resistance in plants |
| topic | Disease resistance E genes Genetic engineering NLRs Plant immunity PRRs |
| url | https://doi.org/10.1002/advs.202412223 |
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