Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study
Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control stu...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/659394 |
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| author | Marco Vinceti Carlotta Malagoli Laura Iacuzio Catherine M. Crespi Sabina Sieri Vittorio Krogh Sandra Marmiroli Giovanni Pellacani Elisabetta Venturelli |
| author_facet | Marco Vinceti Carlotta Malagoli Laura Iacuzio Catherine M. Crespi Sabina Sieri Vittorio Krogh Sandra Marmiroli Giovanni Pellacani Elisabetta Venturelli |
| author_sort | Marco Vinceti |
| collection | DOAJ |
| description | Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size. |
| format | Article |
| id | doaj-art-759f81365af448938e02be5796db7bcf |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-759f81365af448938e02be5796db7bcf2025-02-03T05:45:07ZengWileyDermatology Research and Practice1687-61051687-61132013-01-01201310.1155/2013/659394659394Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control StudyMarco Vinceti0Carlotta Malagoli1Laura Iacuzio2Catherine M. Crespi3Sabina Sieri4Vittorio Krogh5Sandra Marmiroli6Giovanni Pellacani7Elisabetta Venturelli8Departments of Diagnostic, Clinical and Public Health Medicine, Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), University of Modena and Reggio Emilia, Padiglione De Sanctis, Via Amendola 2, 42122 Reggio Emilia, ItalyDepartments of Diagnostic, Clinical and Public Health Medicine, Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), University of Modena and Reggio Emilia, Padiglione De Sanctis, Via Amendola 2, 42122 Reggio Emilia, ItalyDepartments of Diagnostic, Clinical and Public Health Medicine, Environmental, Genetic and Nutritional Epidemiology Research Center (CREAGEN), University of Modena and Reggio Emilia, Padiglione De Sanctis, Via Amendola 2, 42122 Reggio Emilia, ItalyDepartment of Biostatistics, University of California Los Angeles Fielding School of Public Health, Los Angeles, CA 90095-1772, USAEpidemiology and Prevention Unit, National Cancer Institute, Via Venezian 1, 20133 Milan, ItalyEpidemiology and Prevention Unit, National Cancer Institute, Via Venezian 1, 20133 Milan, ItalyDepartment of Surgery, Medicine, Odontoiatrics and Morphological Sciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, ItalyDepartment of Surgery, Medicine, Odontoiatrics and Morphological Sciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124 Modena, ItalyEpidemiology and Prevention Unit, National Cancer Institute, Via Venezian 1, 20133 Milan, ItalyBackground. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was determined in 51 newly diagnosed melanoma patients and 51 age- and sex-matched population controls by extracting total lipids from serum samples using thin layer and gas chromatography. Conditional logistic regression was used to estimate the relative risk of melanoma associated with tertiles of percentage composition of each fatty acid as well as groupings including saturated, monounsaturated, and polyunsaturated fatty acids. Results. We found a slightly increased melanoma risk for stearic and arachidic acids proportion, with and without adjustment for potential confounders. For an n-3 polyunsaturated fatty acid, docosapentaenoic acid, we found a male-specific direct association with melanoma risk. No other associations emerged for the other saturated, monounsaturated, and polyunsaturated fatty acids, individually or grouped by type. Conclusions. These findings do not suggest a major role of fatty acids, including linoleic acid, on risk of cutaneous melanoma, though their evaluation is limited by the small sample size.http://dx.doi.org/10.1155/2013/659394 |
| spellingShingle | Marco Vinceti Carlotta Malagoli Laura Iacuzio Catherine M. Crespi Sabina Sieri Vittorio Krogh Sandra Marmiroli Giovanni Pellacani Elisabetta Venturelli Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study Dermatology Research and Practice |
| title | Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study |
| title_full | Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study |
| title_fullStr | Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study |
| title_full_unstemmed | Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study |
| title_short | Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study |
| title_sort | serum fatty acids and risk of cutaneous melanoma a population based case control study |
| url | http://dx.doi.org/10.1155/2013/659394 |
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