Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity

Spatial deconvolution from bulk DNA methylation profiles determines intratumoral epigenetic heterogeneity

Abstract Background Intratumoral heterogeneity emerges from accumulating genetic and epigenetic changes during tumorigenesis, which may contribute to therapeutic failure and drug resistance. However, the lack of a quick and convenient approach to determine the intratumoral epigenetic heterogeneity (...

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Bibliographic Details
Main Authors: Binbin Liu, Yumo Xie, Yu Zhang, Guannan Tang, Jinxin Lin, Ze Yuan, Xiaoxia Liu, Xiaolin Wang, Meijin Huang, Yanxin Luo, Huichuan Yu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
DNA methylation
Intratumor heterogeneity
Epigenetic
Colorectal cancer
Online Access:https://doi.org/10.1186/s13578-024-01337-y
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