The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia
Objective. The metabolism of three major nutrients (sugar, lipid, and protein) will change during pregnancy, especially in the second trimester. The present study is aimed at evaluating carnitine alteration in fatty acid metabolism in the second trimester of pregnancy and the correlation between car...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/4085757 |
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| _version_ | 1832547154339561472 |
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| author | Man Sun Baihui Zhao Sainan He Ruopeng Weng Binqiao Wang Yunping Ding Xinwen Huang Qiong Luo |
| author_facet | Man Sun Baihui Zhao Sainan He Ruopeng Weng Binqiao Wang Yunping Ding Xinwen Huang Qiong Luo |
| author_sort | Man Sun |
| collection | DOAJ |
| description | Objective. The metabolism of three major nutrients (sugar, lipid, and protein) will change during pregnancy, especially in the second trimester. The present study is aimed at evaluating carnitine alteration in fatty acid metabolism in the second trimester of pregnancy and the correlation between carnitine and GDM. Methods. 450 pregnant women were recruited in the present prospective study. Metabolic profiling of 31 carnitines was detected by LC-MS/MS in these women. Correlation between carnitine metabolism and maternal and neonatal complication with GDM was analyzed. Results. We found the levels of 7 carnitines increased in age>35, BMI≥30, weight gain>20 kg, and ART pregnant groups, but the level of free carnitine (C0) decreased. Nine carnitines were specific metabolites of GDM. Prepregnancy BMI, weight gain, and carnitines (C0, C3, and C16) were independent risk factors associated with GDM and related macrosomia. C0 was negatively correlated with FBG, LDL, TG, and TC. A nomogram was developed for predicting macrosomia in GDM based on carnitine-related metabolic variables. Conclusion. The carnitine metabolism in the second trimester is abnormal in GDM women. The dysfunction of carnitine metabolism is closely related to the abnormality of blood lipid and glucose in GDM. Carnitine metabolism abnormality could predict macrosomia complicated with GDM. |
| format | Article |
| id | doaj-art-757eb54b381d4e39b035b7ca59a5b209 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-757eb54b381d4e39b035b7ca59a5b2092025-02-03T06:45:46ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/40857574085757The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting MacrosomiaMan Sun0Baihui Zhao1Sainan He2Ruopeng Weng3Binqiao Wang4Yunping Ding5Xinwen Huang6Qiong Luo7Department of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaDepartment of Genetic and Metabolic Diseases, The Children’s Hospital, School of Medicine, Zhejiang University, No.1, Xueshi Road, Shangchen District, Hangzhou, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, ChinaObjective. The metabolism of three major nutrients (sugar, lipid, and protein) will change during pregnancy, especially in the second trimester. The present study is aimed at evaluating carnitine alteration in fatty acid metabolism in the second trimester of pregnancy and the correlation between carnitine and GDM. Methods. 450 pregnant women were recruited in the present prospective study. Metabolic profiling of 31 carnitines was detected by LC-MS/MS in these women. Correlation between carnitine metabolism and maternal and neonatal complication with GDM was analyzed. Results. We found the levels of 7 carnitines increased in age>35, BMI≥30, weight gain>20 kg, and ART pregnant groups, but the level of free carnitine (C0) decreased. Nine carnitines were specific metabolites of GDM. Prepregnancy BMI, weight gain, and carnitines (C0, C3, and C16) were independent risk factors associated with GDM and related macrosomia. C0 was negatively correlated with FBG, LDL, TG, and TC. A nomogram was developed for predicting macrosomia in GDM based on carnitine-related metabolic variables. Conclusion. The carnitine metabolism in the second trimester is abnormal in GDM women. The dysfunction of carnitine metabolism is closely related to the abnormality of blood lipid and glucose in GDM. Carnitine metabolism abnormality could predict macrosomia complicated with GDM.http://dx.doi.org/10.1155/2020/4085757 |
| spellingShingle | Man Sun Baihui Zhao Sainan He Ruopeng Weng Binqiao Wang Yunping Ding Xinwen Huang Qiong Luo The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia Journal of Diabetes Research |
| title | The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia |
| title_full | The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia |
| title_fullStr | The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia |
| title_full_unstemmed | The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia |
| title_short | The Alteration of Carnitine Metabolism in Second Trimester in GDM and a Nomogram for Predicting Macrosomia |
| title_sort | alteration of carnitine metabolism in second trimester in gdm and a nomogram for predicting macrosomia |
| url | http://dx.doi.org/10.1155/2020/4085757 |
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