Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina
The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Pat...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/852507 |
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| author | Heng-Jung Hsu Chiung-Hui Yen Kuang-Hung Hsu I-Wen Wu Chin-Chan Lee Chiao-Yin Sun Chia-Chi Chou Chun-Yu Chen Shih-Ying Yang Chi-Jen Tsai Mai-Szu Wu Ming-Jui Hung |
| author_facet | Heng-Jung Hsu Chiung-Hui Yen Kuang-Hung Hsu I-Wen Wu Chin-Chan Lee Chiao-Yin Sun Chia-Chi Chou Chun-Yu Chen Shih-Ying Yang Chi-Jen Tsai Mai-Szu Wu Ming-Jui Hung |
| author_sort | Heng-Jung Hsu |
| collection | DOAJ |
| description | The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1–3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD. |
| format | Article |
| id | doaj-art-75629cd9f19740a2833b6bcfed573318 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-75629cd9f19740a2833b6bcfed5733182025-02-03T06:44:27ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/852507852507Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic AnginaHeng-Jung Hsu0Chiung-Hui Yen1Kuang-Hung Hsu2I-Wen Wu3Chin-Chan Lee4Chiao-Yin Sun5Chia-Chi Chou6Chun-Yu Chen7Shih-Ying Yang8Chi-Jen Tsai9Mai-Szu Wu10Ming-Jui Hung11Department of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Pediatrics, Taipei Medical University Hospital, Taipei 11031, TaiwanLaboratory of Epidemiology, Department of Health Care Management, Chang Gung University, Taoyuan 33302, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung 20401, TaiwanThe Graduate Institute of Clinical Medical Sciences, Chang Gung University Medical College, Taoyuan 33302, TaiwanThe prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1–3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.http://dx.doi.org/10.1155/2014/852507 |
| spellingShingle | Heng-Jung Hsu Chiung-Hui Yen Kuang-Hung Hsu I-Wen Wu Chin-Chan Lee Chiao-Yin Sun Chia-Chi Chou Chun-Yu Chen Shih-Ying Yang Chi-Jen Tsai Mai-Szu Wu Ming-Jui Hung Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina The Scientific World Journal |
| title | Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina |
| title_full | Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina |
| title_fullStr | Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina |
| title_full_unstemmed | Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina |
| title_short | Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina |
| title_sort | chronic kidney disease stage is a modulator on the association between high sensitivity c reactive protein and coronary vasospastic angina |
| url | http://dx.doi.org/10.1155/2014/852507 |
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