Stereotactic Irradiation of GH-Secreting Pituitary Adenomas
Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/482861 |
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| author | G. Minniti C. Scaringi D. Amelio R. Maurizi Enrici |
| author_facet | G. Minniti C. Scaringi D. Amelio R. Maurizi Enrici |
| author_sort | G. Minniti |
| collection | DOAJ |
| description | Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques. |
| format | Article |
| id | doaj-art-7550cf6a204b4ad7aec003068c15fd8b |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7550cf6a204b4ad7aec003068c15fd8b2025-02-03T06:07:44ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/482861482861Stereotactic Irradiation of GH-Secreting Pituitary AdenomasG. Minniti0C. Scaringi1D. Amelio2R. Maurizi Enrici3Department of Neuroscience, Neuromed Institute, 86077 Pozzilli, ItalyDepartment of Radiation Oncology, Sant’Andrea Hospital, University Sapienza, 00189 Rome, ItalyATreP, Agenzia Provinciale per la Protonterapia, 38122 Trento, ItalyDepartment of Radiation Oncology, Sant’Andrea Hospital, University Sapienza, 00189 Rome, ItalyRadiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques.http://dx.doi.org/10.1155/2012/482861 |
| spellingShingle | G. Minniti C. Scaringi D. Amelio R. Maurizi Enrici Stereotactic Irradiation of GH-Secreting Pituitary Adenomas International Journal of Endocrinology |
| title | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
| title_full | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
| title_fullStr | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
| title_full_unstemmed | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
| title_short | Stereotactic Irradiation of GH-Secreting Pituitary Adenomas |
| title_sort | stereotactic irradiation of gh secreting pituitary adenomas |
| url | http://dx.doi.org/10.1155/2012/482861 |
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