Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features
We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/5016840 |
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| _version_ | 1832552018855591936 |
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| author | Ehtasham Ahmad Mohamed Mohamed Apostolos Vrettos |
| author_facet | Ehtasham Ahmad Mohamed Mohamed Apostolos Vrettos |
| author_sort | Ehtasham Ahmad |
| collection | DOAJ |
| description | We present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later. |
| format | Article |
| id | doaj-art-754fe3dd28124e82a0146164659157ad |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-754fe3dd28124e82a0146164659157ad2025-02-03T05:59:48ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/50168405016840Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological FeaturesEhtasham Ahmad0Mohamed Mohamed1Apostolos Vrettos2East Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UKEast Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UKEast Kent Hospitals University NHS Trust, Queen Elizabeth the Queen Mother Hospital, Department of General Internal Medicine, Margate, UKWe present the case of a 43-year-old lady who presented with headaches, visual impairment, and seizures, progressing rapidly over the course of a few weeks. Extensive workup excluded an inflammatory or infectious cause. Imaging studies revealed diffuse thickening of the leptomeninges and serial CSF analysis showed raised opening pressures and increased protein levels. A diagnostic biopsy of the lower thoracic dura confirmed the diagnosis of primary diffuse leptomeningeal gliomatosis (PDGL). She was managed supportively for her symptoms and unfortunately she passed away a few weeks later.http://dx.doi.org/10.1155/2016/5016840 |
| spellingShingle | Ehtasham Ahmad Mohamed Mohamed Apostolos Vrettos Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features Case Reports in Neurological Medicine |
| title | Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features |
| title_full | Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features |
| title_fullStr | Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features |
| title_full_unstemmed | Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features |
| title_short | Primary Diffuse Leptomeningeal Gliomatosis: Radiological/Pathological Features |
| title_sort | primary diffuse leptomeningeal gliomatosis radiological pathological features |
| url | http://dx.doi.org/10.1155/2016/5016840 |
| work_keys_str_mv | AT ehtashamahmad primarydiffuseleptomeningealgliomatosisradiologicalpathologicalfeatures AT mohamedmohamed primarydiffuseleptomeningealgliomatosisradiologicalpathologicalfeatures AT apostolosvrettos primarydiffuseleptomeningealgliomatosisradiologicalpathologicalfeatures |