Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects
Background. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin a...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2018/7497260 |
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| author | Shelly N. Hester Angela Mastaloudis Russell Gray Joseph M. Antony Mal Evans Steven M. Wood |
| author_facet | Shelly N. Hester Angela Mastaloudis Russell Gray Joseph M. Antony Mal Evans Steven M. Wood |
| author_sort | Shelly N. Hester |
| collection | DOAJ |
| description | Background. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results. After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (p<0.001) and Actinobacteria (p<0.001) and a significant increase in Bacteroidetes (p<0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (p<0.05), gas (p=0.035), and abdominal pain (p=0.015) as well as significant improvements in stool consistency (p<0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (p=0.107). The supplement was safe and well tolerated. Conclusions. The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits. |
| format | Article |
| id | doaj-art-753e555741014b21bf899e2ec2e6d1ed |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-753e555741014b21bf899e2ec2e6d1ed2025-02-03T01:33:23ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322018-01-01201810.1155/2018/74972607497260Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female SubjectsShelly N. Hester0Angela Mastaloudis1Russell Gray2Joseph M. Antony3Mal Evans4Steven M. Wood5Pharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USAPharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USAPharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USAKGK Science Inc., 255 Queens Avenue, Suite 1440, London, Ontario, N6A 5R8, CanadaKGK Science Inc., 255 Queens Avenue, Suite 1440, London, Ontario, N6A 5R8, CanadaPharmanex Research, NSE Products Inc., 75 West Center Street, Provo, UT 84601, USABackground. Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem. Objectives. An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation. Results. After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (p<0.001) and Actinobacteria (p<0.001) and a significant increase in Bacteroidetes (p<0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (p<0.05), gas (p=0.035), and abdominal pain (p=0.015) as well as significant improvements in stool consistency (p<0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (p=0.107). The supplement was safe and well tolerated. Conclusions. The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.http://dx.doi.org/10.1155/2018/7497260 |
| spellingShingle | Shelly N. Hester Angela Mastaloudis Russell Gray Joseph M. Antony Mal Evans Steven M. Wood Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects Journal of Nutrition and Metabolism |
| title | Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects |
| title_full | Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects |
| title_fullStr | Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects |
| title_full_unstemmed | Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects |
| title_short | Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects |
| title_sort | efficacy of an anthocyanin and prebiotic blend on intestinal environment in obese male and female subjects |
| url | http://dx.doi.org/10.1155/2018/7497260 |
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