Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration
We have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to chang...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2012/956248 |
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| author | Kunlin Cao Gary E. Christensen Kai Ding Kaifang Du Maghavan L. Raghavan Ryan E. Amelon Kimberly M. Baker Eric A. Hoffman Joseph M. Reinhardt |
| author_facet | Kunlin Cao Gary E. Christensen Kai Ding Kaifang Du Maghavan L. Raghavan Ryan E. Amelon Kimberly M. Baker Eric A. Hoffman Joseph M. Reinhardt |
| author_sort | Kunlin Cao |
| collection | DOAJ |
| description | We have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function. Lung CT datasets from six human subjects were used in this study. Each subject was scanned at four time points before and after BAL procedure. Image registration was performed to align images at different time points and different inflation levels. The resulting dense displacement fields were utilized to track tissue volume changes and reveal deformation patterns of local parenchymal tissue quantitatively. The registration accuracy was assessed by measuring landmark matching errors, which were on the order of 1 mm. The results show that quantitative-assessed fluid volume agreed well with bronchoscopist-reported unretrieved BAL volume in the whole lungs (squared linear correlation coefficient was 0.81). The average difference of lung tissue volume at baseline and after 24 hours was around 2%, which indicates that BAL fluid in the lungs was almost absorbed after 24 hours. Regional lung-function changes correlated with the presence of BAL fluid, and regional function returned to baseline as the fluid was reabsorbed. |
| format | Article |
| id | doaj-art-75361ddf254949a29343e2885d3199eb |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-75361ddf254949a29343e2885d3199eb2025-02-03T07:26:09ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962012-01-01201210.1155/2012/956248956248Tracking Regional Tissue Volume and Function Change in Lung Using Image RegistrationKunlin Cao0Gary E. Christensen1Kai Ding2Kaifang Du3Maghavan L. Raghavan4Ryan E. Amelon5Kimberly M. Baker6Eric A. Hoffman7Joseph M. Reinhardt8GE Global Research, Niskayuna, NY 12309, USADepartment of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA 52242, USADepartment of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USADepartment of Biomedical Engineering, The University of Iowa, 1402A SC, Iowa City, IA 52242, USADepartment of Biomedical Engineering, The University of Iowa, 1402A SC, Iowa City, IA 52242, USADepartment of Biomedical Engineering, The University of Iowa, 1402A SC, Iowa City, IA 52242, USADepartment of Internal Medicine, The University of Iowa, Iowa City, IA 52242, USADepartment of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USADepartment of Biomedical Engineering, The University of Iowa, 1402A SC, Iowa City, IA 52242, USAWe have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function. Lung CT datasets from six human subjects were used in this study. Each subject was scanned at four time points before and after BAL procedure. Image registration was performed to align images at different time points and different inflation levels. The resulting dense displacement fields were utilized to track tissue volume changes and reveal deformation patterns of local parenchymal tissue quantitatively. The registration accuracy was assessed by measuring landmark matching errors, which were on the order of 1 mm. The results show that quantitative-assessed fluid volume agreed well with bronchoscopist-reported unretrieved BAL volume in the whole lungs (squared linear correlation coefficient was 0.81). The average difference of lung tissue volume at baseline and after 24 hours was around 2%, which indicates that BAL fluid in the lungs was almost absorbed after 24 hours. Regional lung-function changes correlated with the presence of BAL fluid, and regional function returned to baseline as the fluid was reabsorbed.http://dx.doi.org/10.1155/2012/956248 |
| spellingShingle | Kunlin Cao Gary E. Christensen Kai Ding Kaifang Du Maghavan L. Raghavan Ryan E. Amelon Kimberly M. Baker Eric A. Hoffman Joseph M. Reinhardt Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration International Journal of Biomedical Imaging |
| title | Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration |
| title_full | Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration |
| title_fullStr | Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration |
| title_full_unstemmed | Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration |
| title_short | Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration |
| title_sort | tracking regional tissue volume and function change in lung using image registration |
| url | http://dx.doi.org/10.1155/2012/956248 |
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