HIV infection drives proinflammatory adipocyte differentiation in an in vitro model and reveals a new inflammatory pathway

HIV infection drives proinflammatory adipocyte differentiation in an in vitro model and reveals a new inflammatory pathway

IntroductionAdipose tissue regulates metabolic homeostasis and serves as a reservoir for mesenchymal stem cells (MSCs), which differentiate into osteoblasts and adipocytes, balancing bone and lipid metabolism. Bone loss and fat accumulation are common in individuals living with HIV, prompting us to...

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Bibliographic Details
Main Authors: Rosa Nicole Freiberger, Cynthia Alicia Marcela López, Franco Agustin Sviercz, Patricio Jarmoluk, María Belén Palma, Marcela Nilda García, Jorge Quarleri, M. Victoria Delpino
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
HIV
adipocyte
MSCs
lipid droplets (LD)
adipogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1627963/full
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