Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest
Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines ar...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/670580 |
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| author | Julie Mondet Kais Hussein Pascal Mossuz |
| author_facet | Julie Mondet Kais Hussein Pascal Mossuz |
| author_sort | Julie Mondet |
| collection | DOAJ |
| description | Cytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed. |
| format | Article |
| id | doaj-art-75304fca8ce14d7c8344c765af620628 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-75304fca8ce14d7c8344c765af6206282025-02-03T01:09:45ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/670580670580Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic InterestJulie Mondet0Kais Hussein1Pascal Mossuz2UF de Pathologie Moléculaire, Département d’Anatomie et Cytologie Pathologiques, CHU Grenoble, 38043 Grenoble Cedex 09, FranceInstitute of Pathology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyEquipe TheRex Laboratoire TIMC-IMAG-UMR5525 CNRS, Université Grenoble Alpes, FranceCytokines are well known mediators of numerous physiological and pathological processes. They contribute to the regulation of normal hematopoiesis but increasing data suggest that they also have a clinical impact in some hematopoietic malignancies. In particular, there is evidence that cytokines are implicated in the functional symptoms of Philadelphia negative myeloproliferative neoplasms (Ph− MPNs), suggesting that evaluation of circulating levels of cytokines could be of clinical interest for the characterization of patients at the time of diagnosis and for disease prognosis. In this review, we present the current knowledge on alteration of circulating cytokine profiles in MPNs and their role in myelofibrosis pathogenesis. Phenotypic correlation, prognostic value of cytokines, and impact of JAK inhibitors are also discussed.http://dx.doi.org/10.1155/2015/670580 |
| spellingShingle | Julie Mondet Kais Hussein Pascal Mossuz Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest Mediators of Inflammation |
| title | Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest |
| title_full | Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest |
| title_fullStr | Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest |
| title_full_unstemmed | Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest |
| title_short | Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest |
| title_sort | circulating cytokine levels as markers of inflammation in philadelphia negative myeloproliferative neoplasms diagnostic and prognostic interest |
| url | http://dx.doi.org/10.1155/2015/670580 |
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