Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality
A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African f...
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Wiley
2011-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/706304 |
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| author | Mogens Helweg Claesson |
| author_facet | Mogens Helweg Claesson |
| author_sort | Mogens Helweg Claesson |
| collection | DOAJ |
| description | A number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits of Bacillus Calmette-Guerin (BCG) vaccination. From an immunological point of view, we hypothesise that the adverse effects of DTwP vaccine may occur because of the Th2-polarising effect of the aluminium phosphate adjuvant in the vaccine and because intramuscular administration of the vaccine may cause chronic inflammation at the site of injection. However, the Th1-polarising effect of BCG is likely to be beneficial. Sexual dimorphism affecting immune functions and vitamin A supplementation may influence both the deleterious and beneficial nonspecific effects of immunisation. |
| format | Article |
| id | doaj-art-752e88d363574e4ea9f82a46704411fb |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-752e88d363574e4ea9f82a46704411fb2025-02-03T05:51:40ZengWileyJournal of Tropical Medicine1687-96861687-96942011-01-01201110.1155/2011/706304706304Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant MortalityMogens Helweg Claesson0Laboratory for Experimental and Cellular Immunology, Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, DenmarkA number of mainly observational studies suggest that many African females below the age of one year die each year from the nonspecific effects of vaccination with diphtheria-tetanus toxoids and killed (whole-cell) Bordetella pertussis (DTwP). In contrast, similar studies suggest that many African females and males may have their lives saved each year by the nonspecific immunological benefits of Bacillus Calmette-Guerin (BCG) vaccination. From an immunological point of view, we hypothesise that the adverse effects of DTwP vaccine may occur because of the Th2-polarising effect of the aluminium phosphate adjuvant in the vaccine and because intramuscular administration of the vaccine may cause chronic inflammation at the site of injection. However, the Th1-polarising effect of BCG is likely to be beneficial. Sexual dimorphism affecting immune functions and vitamin A supplementation may influence both the deleterious and beneficial nonspecific effects of immunisation.http://dx.doi.org/10.1155/2011/706304 |
| spellingShingle | Mogens Helweg Claesson Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality Journal of Tropical Medicine |
| title | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality |
| title_full | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality |
| title_fullStr | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality |
| title_full_unstemmed | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality |
| title_short | Immunological Links to Nonspecific Effects of DTwP and BCG Vaccines on Infant Mortality |
| title_sort | immunological links to nonspecific effects of dtwp and bcg vaccines on infant mortality |
| url | http://dx.doi.org/10.1155/2011/706304 |
| work_keys_str_mv | AT mogenshelwegclaesson immunologicallinkstononspecificeffectsofdtwpandbcgvaccinesoninfantmortality |