Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children
Langerhans cell histiocytosis (LCH) is a disease caused by clonal expansion of CD1a+/CD207+ cells and is characterized by organ involvement and dysfunction. Treatment of LCH in children is risk-adapted, and multisystem LCH requires systemic therapy. Although systemic treatments such as chemotherapy...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1345855/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583788737069056 |
|---|---|
| author | Guangqiang Meng Saran Feng Yan Wang |
| author_facet | Guangqiang Meng Saran Feng Yan Wang |
| author_sort | Guangqiang Meng |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a disease caused by clonal expansion of CD1a+/CD207+ cells and is characterized by organ involvement and dysfunction. Treatment of LCH in children is risk-adapted, and multisystem LCH requires systemic therapy. Although systemic treatments such as chemotherapy and BRAF/MEK inhibitors have improved the cure rate of LCH, disease reactivation rates remain 30%, and eventually some patients progress to relapse-refractory LCH. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a promising salvage treatment strategy for children with relapse-refractory LCH. However, many questions such as the efficacy and indications of allo-HSCT, as well as suitable conditioning regimen are still undetermined for children with LCH. This review aimed to provide an update on advances in allo-HSCT for LCH in children, including indications, stem cell sources, conditioning regimens, chimerism, transplant-related complications, outcomes, and treatment of relapse. |
| format | Article |
| id | doaj-art-752240ca266741dea29fca3a22f9cb73 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-752240ca266741dea29fca3a22f9cb732025-01-28T06:40:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.13458551345855Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in childrenGuangqiang MengSaran FengYan WangLangerhans cell histiocytosis (LCH) is a disease caused by clonal expansion of CD1a+/CD207+ cells and is characterized by organ involvement and dysfunction. Treatment of LCH in children is risk-adapted, and multisystem LCH requires systemic therapy. Although systemic treatments such as chemotherapy and BRAF/MEK inhibitors have improved the cure rate of LCH, disease reactivation rates remain 30%, and eventually some patients progress to relapse-refractory LCH. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a promising salvage treatment strategy for children with relapse-refractory LCH. However, many questions such as the efficacy and indications of allo-HSCT, as well as suitable conditioning regimen are still undetermined for children with LCH. This review aimed to provide an update on advances in allo-HSCT for LCH in children, including indications, stem cell sources, conditioning regimens, chimerism, transplant-related complications, outcomes, and treatment of relapse.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1345855/fullLangerhans cell histiocytosisallogeneic hematopoietic stem cell transplantationmyeloablative conditioningreduced intensity conditioningchimerism |
| spellingShingle | Guangqiang Meng Saran Feng Yan Wang Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children Frontiers in Immunology Langerhans cell histiocytosis allogeneic hematopoietic stem cell transplantation myeloablative conditioning reduced intensity conditioning chimerism |
| title | Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children |
| title_full | Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children |
| title_fullStr | Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children |
| title_full_unstemmed | Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children |
| title_short | Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children |
| title_sort | advances in allogeneic hematopoietic stem cell transplantation for langerhans cell histiocytosis in children |
| topic | Langerhans cell histiocytosis allogeneic hematopoietic stem cell transplantation myeloablative conditioning reduced intensity conditioning chimerism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1345855/full |
| work_keys_str_mv | AT guangqiangmeng advancesinallogeneichematopoieticstemcelltransplantationforlangerhanscellhistiocytosisinchildren AT saranfeng advancesinallogeneichematopoieticstemcelltransplantationforlangerhanscellhistiocytosisinchildren AT yanwang advancesinallogeneichematopoieticstemcelltransplantationforlangerhanscellhistiocytosisinchildren |