Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial
Abstract Background To investigate whether continuous intervention using soymilk containing high soy protein improves physical frailty, a randomized controlled trial was conducted among the Japanese pre-frail and frail elderly. Methods Japanese pre-frail and frail elderly participants (n = 73) were...
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BMC
2025-01-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-024-05539-4 |
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| author | Nene Sato Yuji Terashima Makoto Sugawara Ryoichi Unno Hiroaki Asao Mitsuhiro Iwasaki Tomoyuki Watanabe Tomoko Uno Mitsuo Maruyama |
| author_facet | Nene Sato Yuji Terashima Makoto Sugawara Ryoichi Unno Hiroaki Asao Mitsuhiro Iwasaki Tomoyuki Watanabe Tomoko Uno Mitsuo Maruyama |
| author_sort | Nene Sato |
| collection | DOAJ |
| description | Abstract Background To investigate whether continuous intervention using soymilk containing high soy protein improves physical frailty, a randomized controlled trial was conducted among the Japanese pre-frail and frail elderly. Methods Japanese pre-frail and frail elderly participants (n = 73) were randomly assigned to the high-soy protein and control groups, who then ingested soymilk containing 14.5 g/200 ml and 3.2 g/200 ml of soy protein, respectively. Before and after the 12-week intervention, walking speed, skeletal muscle mass, grip strength, and the revised Japanese CHS questionnaire regarding fatigue and physical activity were examined to evaluate the impact of each soymilk on physical frailty and compare the variation between the two groups. Physical activity (monitored using a pedometer), dietary intake (determined by questionnaire), and estimated protein intake (determined by casual urine testing) were also recorded before and after the intervention. Results For the final analysis of the entire cohort (n = 70), there were no significant differences in the endpoints between the two groups. In the subgroup analysis, among participants with a walking speed of at least 1 m/s (n = 35, P = 0.012) and at least 5,000 steps/day before intervention (n = 27, P = 0.0083), the variation in walking speed after the 12-week intervention was significantly higher in the high-soy protein group than in the control group. Estimated protein intake was also significantly higher in the high-soy protein group than in the control group after the intervention. Regarding physical activity and dietary intake, no significant differences were observed between the groups before or after the intervention. Conclusion The continuous 12-week intervention of high soy protein increased the walking speed among the Japanese pre-frail and frail elderly participants who had an ordinarily high walking speed and high step counts. Trial registration UMIN Clinical Trials Registry, UMIN000044999. Registered July 29, 2021; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051409 . |
| format | Article |
| id | doaj-art-751e8513bcad4533a2ff35ee46313fae |
| institution | Kabale University |
| issn | 1471-2318 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Geriatrics |
| spelling | doaj-art-751e8513bcad4533a2ff35ee46313fae2025-01-19T12:38:07ZengBMCBMC Geriatrics1471-23182025-01-0125111010.1186/s12877-024-05539-4Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trialNene Sato0Yuji Terashima1Makoto Sugawara2Ryoichi Unno3Hiroaki Asao4Mitsuhiro Iwasaki5Tomoyuki Watanabe6Tomoko Uno7Mitsuo Maruyama8Research and Development Division, MARUSAN-AI Co., Ltd.Research and Development Division, MARUSAN-AI Co., Ltd.Research and Development Division, MARUSAN-AI Co., Ltd.Research and Development Division, MARUSAN-AI Co., Ltd.Research and Development Division, MARUSAN-AI Co., Ltd.Research and Development Division, MARUSAN-AI Co., Ltd.Department of Health and Nutritional Sciences, Faculty of Health Sciences, Aichi Gakuin UniversityDepartment of Health and Nutritional Sciences, Faculty of Health Sciences, Aichi Gakuin UniversityGeroscience Research Center, Research Institute, National Center for Geriatrics and GerontologyAbstract Background To investigate whether continuous intervention using soymilk containing high soy protein improves physical frailty, a randomized controlled trial was conducted among the Japanese pre-frail and frail elderly. Methods Japanese pre-frail and frail elderly participants (n = 73) were randomly assigned to the high-soy protein and control groups, who then ingested soymilk containing 14.5 g/200 ml and 3.2 g/200 ml of soy protein, respectively. Before and after the 12-week intervention, walking speed, skeletal muscle mass, grip strength, and the revised Japanese CHS questionnaire regarding fatigue and physical activity were examined to evaluate the impact of each soymilk on physical frailty and compare the variation between the two groups. Physical activity (monitored using a pedometer), dietary intake (determined by questionnaire), and estimated protein intake (determined by casual urine testing) were also recorded before and after the intervention. Results For the final analysis of the entire cohort (n = 70), there were no significant differences in the endpoints between the two groups. In the subgroup analysis, among participants with a walking speed of at least 1 m/s (n = 35, P = 0.012) and at least 5,000 steps/day before intervention (n = 27, P = 0.0083), the variation in walking speed after the 12-week intervention was significantly higher in the high-soy protein group than in the control group. Estimated protein intake was also significantly higher in the high-soy protein group than in the control group after the intervention. Regarding physical activity and dietary intake, no significant differences were observed between the groups before or after the intervention. Conclusion The continuous 12-week intervention of high soy protein increased the walking speed among the Japanese pre-frail and frail elderly participants who had an ordinarily high walking speed and high step counts. Trial registration UMIN Clinical Trials Registry, UMIN000044999. Registered July 29, 2021; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051409 .https://doi.org/10.1186/s12877-024-05539-4FrailtySoy proteinSoymilkNutritional interventionWalking speed |
| spellingShingle | Nene Sato Yuji Terashima Makoto Sugawara Ryoichi Unno Hiroaki Asao Mitsuhiro Iwasaki Tomoyuki Watanabe Tomoko Uno Mitsuo Maruyama Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial BMC Geriatrics Frailty Soy protein Soymilk Nutritional intervention Walking speed |
| title | Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial |
| title_full | Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial |
| title_fullStr | Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial |
| title_full_unstemmed | Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial |
| title_short | Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial |
| title_sort | continuous high soy protein soymilk intake affects ordinary walking speed in the japanese pre frail and frail elderly a randomized controlled trial |
| topic | Frailty Soy protein Soymilk Nutritional intervention Walking speed |
| url | https://doi.org/10.1186/s12877-024-05539-4 |
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