Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial
Aims: This study evaluated the effects of circuit resistance training (CRT), a vegetarian/Mediterranean diet (VegMedD), and empagliflozin on Resting Metabolic Rate (RMR) in older adults with Type 2 Diabetes (T2DM). Methods: 67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly ass...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024176244 |
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| author | Assaf Buch Roy Eldor Ofer Kis Arie Ben-Yehuda Gizell Green Yona Greenman Sharon Barak |
| author_facet | Assaf Buch Roy Eldor Ofer Kis Arie Ben-Yehuda Gizell Green Yona Greenman Sharon Barak |
| author_sort | Assaf Buch |
| collection | DOAJ |
| description | Aims: This study evaluated the effects of circuit resistance training (CRT), a vegetarian/Mediterranean diet (VegMedD), and empagliflozin on Resting Metabolic Rate (RMR) in older adults with Type 2 Diabetes (T2DM). Methods: 67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly assigned to CRT, VegMedD, or empagliflozin for 10 weeks. Assessments included RMR, medical, metabolic, nutritional, anthropometric and functional measurements. RMR changes were analyzed using paired t-tests, effect sizes, and repeated analysis of variance. Results: No significant RMR differences were found between groups at baseline and post-intervention with minor RMR increases in 16 (CRT) to 25 % (VegMeD/empagliflozin). Factors correlating with RMR changes included sleep hours (r = 0.25), fat percentage (r = −0.27), leg strength (r = 0.29), and systolic blood pressure (r = 0.24). Except for blood pressure, all the other variables predicted RMR changes (R2 = 0.22). Conclusions: CRT, VegMedD, and empagliflozin showed similar effects on RMR in elderly with T2DM. Factors predicting changes in RMR are sleep hours, fat percentage, and leg strength, with those who increased/did not change their RMR presenting greater improvement in the aforementioned variables. These findings highlight the potential of these factors as therapeutic targets for improving metabolic health and warrant further investigation. |
| format | Article |
| id | doaj-art-750e242d64f64124b2a5ef1f4297a574 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| spelling | doaj-art-750e242d64f64124b2a5ef1f4297a5742025-02-02T05:27:52ZengElsevierHeliyon2405-84402025-01-01112e41593Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trialAssaf Buch0Roy Eldor1Ofer Kis2Arie Ben-Yehuda3Gizell Green4Yona Greenman5Sharon Barak6Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel, Israel; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Corresponding author. Department of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel, Israel, Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Health Systems Management, Ariel University, Ariel, IsraelInstitute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Nursing, School of Health Sciences, Ariel University, Ariel, IsraelDepartment of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Nutritional Sciences, School of Health Sciences, Ariel University, Ariel, Israel; Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; Department of Health Systems Management, Ariel University, Ariel, Israel; Department of Nursing, School of Health Sciences, Ariel University, Ariel, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Pediatric Rehabilitation, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, Israel; Department of Nursing, Max Stern Yezreel Valley College, Israel; Shoham Geriatric Medical Center, IsraelInstitute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Nursing, School of Health Sciences, Ariel University, Ariel, Israel; Department of Pediatric Rehabilitation, The Edmond and Lily Safra Children's Hospital, The Chaim Sheba Medical Center, Tel Hashomer, Ramat-Gan, IsraelAims: This study evaluated the effects of circuit resistance training (CRT), a vegetarian/Mediterranean diet (VegMedD), and empagliflozin on Resting Metabolic Rate (RMR) in older adults with Type 2 Diabetes (T2DM). Methods: 67 participants from CEV-65 trial (≥65 years, 61 % female) were randomly assigned to CRT, VegMedD, or empagliflozin for 10 weeks. Assessments included RMR, medical, metabolic, nutritional, anthropometric and functional measurements. RMR changes were analyzed using paired t-tests, effect sizes, and repeated analysis of variance. Results: No significant RMR differences were found between groups at baseline and post-intervention with minor RMR increases in 16 (CRT) to 25 % (VegMeD/empagliflozin). Factors correlating with RMR changes included sleep hours (r = 0.25), fat percentage (r = −0.27), leg strength (r = 0.29), and systolic blood pressure (r = 0.24). Except for blood pressure, all the other variables predicted RMR changes (R2 = 0.22). Conclusions: CRT, VegMedD, and empagliflozin showed similar effects on RMR in elderly with T2DM. Factors predicting changes in RMR are sleep hours, fat percentage, and leg strength, with those who increased/did not change their RMR presenting greater improvement in the aforementioned variables. These findings highlight the potential of these factors as therapeutic targets for improving metabolic health and warrant further investigation.http://www.sciencedirect.com/science/article/pii/S2405844024176244Body compositionCircuit resistance trainingDiabetesEmpagliflozinLower body leg strengthOlder adults |
| spellingShingle | Assaf Buch Roy Eldor Ofer Kis Arie Ben-Yehuda Gizell Green Yona Greenman Sharon Barak Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial Heliyon Body composition Circuit resistance training Diabetes Empagliflozin Lower body leg strength Older adults |
| title | Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial |
| title_full | Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial |
| title_fullStr | Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial |
| title_full_unstemmed | Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial |
| title_short | Metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes– results from the CEV-65 randomized trial |
| title_sort | metabolic and functional factors associated with a change in resting metabolic rate among older adults with type 2 diabetes results from the cev 65 randomized trial |
| topic | Body composition Circuit resistance training Diabetes Empagliflozin Lower body leg strength Older adults |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024176244 |
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